The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis

2014
Authors
Culafić-Vojinović, VioletaĆulafić, Đorđe
Ignjatović, Svetlana

Petakov, Milan
Đurović-Nikolić, Marina
Vasić, Jelena
Mirković, Duško

Mijac, Dragana
Stulić, Miloš
Article (Published version)

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Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=...0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.
Keywords:
liver cirrhosis / osteoporosis / osteocalcin / beta-CTXSource:
Journal of Medical Biochemistry, 2014, 33, 2, 149-155Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.2478/jomb-2013-0025
ISSN: 1452-8258
WoS: 000332683700003
Scopus: 2-s2.0-84896860607
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PharmacyTY - JOUR AU - Culafić-Vojinović, Violeta AU - Ćulafić, Đorđe AU - Ignjatović, Svetlana AU - Petakov, Milan AU - Đurović-Nikolić, Marina AU - Vasić, Jelena AU - Mirković, Duško AU - Mijac, Dragana AU - Stulić, Miloš PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2146 AB - Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis VL - 33 IS - 2 SP - 149 EP - 155 DO - 10.2478/jomb-2013-0025 ER -
@article{ author = "Culafić-Vojinović, Violeta and Ćulafić, Đorđe and Ignjatović, Svetlana and Petakov, Milan and Đurović-Nikolić, Marina and Vasić, Jelena and Mirković, Duško and Mijac, Dragana and Stulić, Miloš", year = "2014", abstract = "Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis", volume = "33", number = "2", pages = "149-155", doi = "10.2478/jomb-2013-0025" }
Culafić-Vojinović, V., Ćulafić, Đ., Ignjatović, S., Petakov, M., Đurović-Nikolić, M., Vasić, J., Mirković, D., Mijac, D.,& Stulić, M.. (2014). The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(2), 149-155. https://doi.org/10.2478/jomb-2013-0025
Culafić-Vojinović V, Ćulafić Đ, Ignjatović S, Petakov M, Đurović-Nikolić M, Vasić J, Mirković D, Mijac D, Stulić M. The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry. 2014;33(2):149-155. doi:10.2478/jomb-2013-0025 .
Culafić-Vojinović, Violeta, Ćulafić, Đorđe, Ignjatović, Svetlana, Petakov, Milan, Đurović-Nikolić, Marina, Vasić, Jelena, Mirković, Duško, Mijac, Dragana, Stulić, Miloš, "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis" in Journal of Medical Biochemistry, 33, no. 2 (2014):149-155, https://doi.org/10.2478/jomb-2013-0025 . .