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The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis

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2014
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Authors
Culafić-Vojinović, Violeta
Ćulafić, Đorđe
Ignjatović, Svetlana
Petakov, Milan
Đurović-Nikolić, Marina
Vasić, Jelena
Mirković, Duško
Mijac, Dragana
Stulić, Miloš
Article (Published version)
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Abstract
Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=...0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.

Keywords:
liver cirrhosis / osteoporosis / osteocalcin / beta-CTX
Source:
Journal of Medical Biochemistry, 2014, 33, 2, 149-155
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita
Projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.2478/jomb-2013-0025

ISSN: 1452-8258

WoS: 000332683700003

Scopus: 2-s2.0-84896860607
[ Google Scholar ]
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2146
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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