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dc.creatorStanković, Milena N.
dc.creatorMladenović, Dušan
dc.creatorĐuričić, Ivana
dc.creatorŠobajić, Slađana
dc.creatorTimić, Jasmina
dc.creatorJorgačević, Bojan
dc.creatorAleksić, Vuk
dc.creatorVucević, Danijela B.
dc.creatorJesić-Vukicević, Rada
dc.creatorRadosavljević, Tatjana S.
dc.date.accessioned2019-09-02T11:40:24Z
dc.date.available2019-09-02T11:40:24Z
dc.date.issued2014
dc.identifier.issn0188-4409
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2153
dc.description.abstractBackground and Aims. Methionine-choline deficient (MCD) diet duration necessary for development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile and fatty acids are not completely established. The study examined dynamics and association between liver free fatty acids (FFA), serum lipid profile and liver morphological changes on MCD diet-induced NAFLD in mice. Methods. Male C57BL/6 mice (n = 28) were divided into four groups (n = 7 per group): control: fed with standard chow, MCD diet-fed groups: 2, 4 or 6 weeks. After treatment, liver and blood samples were taken for histopathology, serum lipid profile, and liver FFA composition. Results. Hepatic FFA profile showed a decrease in saturated acids, arachidonic and docosahexaenoic acid, whereas proportions of docosapentaenoic, oleic and linoleic acid were increased. Total cholesterol, HDL and triglycerides progressively decreased, whereas LDL level progressively increased. Focal fatty change in the liver appeared after 2 weeks, whereas diffuse fatty change with severe inflammation and ballooned hepatocytes were evident after 6 weeks. Conclusions. Six-week diet model may be appropriate for investigation of the role of lipotoxicity in the progression of NAFLD. Therefore, supplementation with n-3 polyunsaturated acid like DHA, rather than DPA, especially in the initial stage of fatty liver disease, may potentially have preventive effects and alleviate development of NAFLD/NASH and may also potentially reduce cardiovascular risk by moderating dyslipidemia.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175015/RS//
dc.rightsrestrictedAccess
dc.sourceArchives of Medical Research
dc.subjectFree fatty acidsen
dc.subjectLipid statusen
dc.subjectMethionine-choline deficient dieten
dc.subjectNAFLDen
dc.subjectMiceen
dc.titleTime-dependent Changes and Association Between Liver Free Fatty Acids, Serum Lipid Profile and Histological Features in Mice Model of Nonalcoholic Fatty Liver Diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВуцевић, Данијела Б.; Радосављевић, Татјана С.; Тимић, Јасмина; Јоргачевић, Бојан; Младеновић, Душан; Станковић, Милена Н.; Ђуричић, Ивана; Јесић-Вукицевић, Рада; Aлексић, Вук; Шобајић, Слађана;
dc.citation.volume45
dc.citation.issue2
dc.citation.spage116
dc.citation.epage124
dc.citation.other45(2): 116-124
dc.citation.rankM22
dc.identifier.wos000333139100002
dc.identifier.doi10.1016/j.arcmed.2013.12.010
dc.identifier.pmid24480733
dc.identifier.scopus2-s2.0-84896879418
dc.identifier.rcubconv_3041
dc.type.versionpublishedVersion


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