Medication use in pregnancy: a cross-sectional, multinational web-based study

2014
Authors
Lupattelli, Angela
Spigset, Olav
Twigg, Michael J.

Zagorodnikova, Ksenia

Mardby, Ann-Charlotte

Moretti, Myla E.
Drozd, Mariola

Panchaud, Alice

Haemeen-Anttila, Katri
Rieutord, Andre

Juraski, R. Gjergja
Odalović, Marina

Kennedy, Debra
Rudolf, Gorazd
Juch, Herbert
Passier, Anneke
Bjoernsdottir, Ingunn
Nordeng, Hedvig
Article (Published version)
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Show full item recordAbstract
Objectives Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication utilised and indication for use. Design Cross-sectional, web-based study performed within the period from 1 October 2011 to 29 February 2012. Uniform collection of drug utilisation data was performed via an anonymous online questionnaire. Setting Multinational study in Europe (Western, Northern and Eastern), North and South America and Australia. Participants Pregnant women and new mothers with children less than 1year of age. Primary and secondary outcome measures Prevalence of and factors associated with medication use for acute/short-term illnesses, chronic/long-term disorders and over-the-counter (OTC) medication use. Results The study population included 9459 women, of... which 81.2% reported use of at least one medication (prescribed or OTC) during pregnancy. Overall, OTC medication use occurred in 66.9% of the pregnancies, whereas 68.4% and 17% of women reported use of at least one medication for treatment of acute/short-term illnesses and chronic/long-term disorders, respectively. The extent of self-reported medicated illnesses and types of medication used by indication varied across regions, especially in relation to urinary tract infections, depression or OTC nasal sprays. Women with higher age or lower educational level, housewives or women with an unplanned pregnancy were those most often reporting use of medication for chronic/long-term disorders. Immigrant women in Western (adjusted OR (aOR): 0.55, 95% CI 0.34 to 0.87) and Northern Europe (aOR: 0.50, 95% CI 0.31 to 0.83) were less likely to report use of medication for chronic/long-term disorders during pregnancy than non-immigrants. Conclusions In this study, the majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy. There was a substantial inter-region variability in the types of medication used.
Keywords:
Maternal medicine / Therapeutics / Public HealthSource:
BMJ Open, 2014, 4, 2Publisher:
- BMJ PUBLISHING GROUP, LONDON
Funding / projects:
- Norwegian Research Council - 216771/F11
- Norwegian Pharmaceutical Society
DOI: 10.1136/bmjopen-2013-004365
ISSN: 2044-6055
PubMed: 24534260
WoS: 000334459100076
Scopus: 2-s2.0-84896690437
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Institution/Community
PharmacyTY - JOUR AU - Lupattelli, Angela AU - Spigset, Olav AU - Twigg, Michael J. AU - Zagorodnikova, Ksenia AU - Mardby, Ann-Charlotte AU - Moretti, Myla E. AU - Drozd, Mariola AU - Panchaud, Alice AU - Haemeen-Anttila, Katri AU - Rieutord, Andre AU - Juraski, R. Gjergja AU - Odalović, Marina AU - Kennedy, Debra AU - Rudolf, Gorazd AU - Juch, Herbert AU - Passier, Anneke AU - Bjoernsdottir, Ingunn AU - Nordeng, Hedvig PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2154 AB - Objectives Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication utilised and indication for use. Design Cross-sectional, web-based study performed within the period from 1 October 2011 to 29 February 2012. Uniform collection of drug utilisation data was performed via an anonymous online questionnaire. Setting Multinational study in Europe (Western, Northern and Eastern), North and South America and Australia. Participants Pregnant women and new mothers with children less than 1year of age. Primary and secondary outcome measures Prevalence of and factors associated with medication use for acute/short-term illnesses, chronic/long-term disorders and over-the-counter (OTC) medication use. Results The study population included 9459 women, of which 81.2% reported use of at least one medication (prescribed or OTC) during pregnancy. Overall, OTC medication use occurred in 66.9% of the pregnancies, whereas 68.4% and 17% of women reported use of at least one medication for treatment of acute/short-term illnesses and chronic/long-term disorders, respectively. The extent of self-reported medicated illnesses and types of medication used by indication varied across regions, especially in relation to urinary tract infections, depression or OTC nasal sprays. Women with higher age or lower educational level, housewives or women with an unplanned pregnancy were those most often reporting use of medication for chronic/long-term disorders. Immigrant women in Western (adjusted OR (aOR): 0.55, 95% CI 0.34 to 0.87) and Northern Europe (aOR: 0.50, 95% CI 0.31 to 0.83) were less likely to report use of medication for chronic/long-term disorders during pregnancy than non-immigrants. Conclusions In this study, the majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy. There was a substantial inter-region variability in the types of medication used. PB - BMJ PUBLISHING GROUP, LONDON T2 - BMJ Open T1 - Medication use in pregnancy: a cross-sectional, multinational web-based study VL - 4 IS - 2 DO - 10.1136/bmjopen-2013-004365 ER -
@article{ author = "Lupattelli, Angela and Spigset, Olav and Twigg, Michael J. and Zagorodnikova, Ksenia and Mardby, Ann-Charlotte and Moretti, Myla E. and Drozd, Mariola and Panchaud, Alice and Haemeen-Anttila, Katri and Rieutord, Andre and Juraski, R. Gjergja and Odalović, Marina and Kennedy, Debra and Rudolf, Gorazd and Juch, Herbert and Passier, Anneke and Bjoernsdottir, Ingunn and Nordeng, Hedvig", year = "2014", abstract = "Objectives Intercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication utilised and indication for use. Design Cross-sectional, web-based study performed within the period from 1 October 2011 to 29 February 2012. Uniform collection of drug utilisation data was performed via an anonymous online questionnaire. Setting Multinational study in Europe (Western, Northern and Eastern), North and South America and Australia. Participants Pregnant women and new mothers with children less than 1year of age. Primary and secondary outcome measures Prevalence of and factors associated with medication use for acute/short-term illnesses, chronic/long-term disorders and over-the-counter (OTC) medication use. Results The study population included 9459 women, of which 81.2% reported use of at least one medication (prescribed or OTC) during pregnancy. Overall, OTC medication use occurred in 66.9% of the pregnancies, whereas 68.4% and 17% of women reported use of at least one medication for treatment of acute/short-term illnesses and chronic/long-term disorders, respectively. The extent of self-reported medicated illnesses and types of medication used by indication varied across regions, especially in relation to urinary tract infections, depression or OTC nasal sprays. Women with higher age or lower educational level, housewives or women with an unplanned pregnancy were those most often reporting use of medication for chronic/long-term disorders. Immigrant women in Western (adjusted OR (aOR): 0.55, 95% CI 0.34 to 0.87) and Northern Europe (aOR: 0.50, 95% CI 0.31 to 0.83) were less likely to report use of medication for chronic/long-term disorders during pregnancy than non-immigrants. Conclusions In this study, the majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy. There was a substantial inter-region variability in the types of medication used.", publisher = "BMJ PUBLISHING GROUP, LONDON", journal = "BMJ Open", title = "Medication use in pregnancy: a cross-sectional, multinational web-based study", volume = "4", number = "2", doi = "10.1136/bmjopen-2013-004365" }
Lupattelli, A., Spigset, O., Twigg, M. J., Zagorodnikova, K., Mardby, A., Moretti, M. E., Drozd, M., Panchaud, A., Haemeen-Anttila, K., Rieutord, A., Juraski, R. G., Odalović, M., Kennedy, D., Rudolf, G., Juch, H., Passier, A., Bjoernsdottir, I.,& Nordeng, H.. (2014). Medication use in pregnancy: a cross-sectional, multinational web-based study. in BMJ Open BMJ PUBLISHING GROUP, LONDON., 4(2). https://doi.org/10.1136/bmjopen-2013-004365
Lupattelli A, Spigset O, Twigg MJ, Zagorodnikova K, Mardby A, Moretti ME, Drozd M, Panchaud A, Haemeen-Anttila K, Rieutord A, Juraski RG, Odalović M, Kennedy D, Rudolf G, Juch H, Passier A, Bjoernsdottir I, Nordeng H. Medication use in pregnancy: a cross-sectional, multinational web-based study. in BMJ Open. 2014;4(2). doi:10.1136/bmjopen-2013-004365 .
Lupattelli, Angela, Spigset, Olav, Twigg, Michael J., Zagorodnikova, Ksenia, Mardby, Ann-Charlotte, Moretti, Myla E., Drozd, Mariola, Panchaud, Alice, Haemeen-Anttila, Katri, Rieutord, Andre, Juraski, R. Gjergja, Odalović, Marina, Kennedy, Debra, Rudolf, Gorazd, Juch, Herbert, Passier, Anneke, Bjoernsdottir, Ingunn, Nordeng, Hedvig, "Medication use in pregnancy: a cross-sectional, multinational web-based study" in BMJ Open, 4, no. 2 (2014), https://doi.org/10.1136/bmjopen-2013-004365 . .