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dc.creatorĐuriš, Jelena
dc.creatorVasiljević, Dragana
dc.creatorJokić, S.
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:40:46Z
dc.date.available2019-09-02T11:40:46Z
dc.date.issued2014
dc.identifier.issn0142-5463
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2168
dc.description.abstractObjectiveThis study investigates the application of D-optimal mixture experimental design in optimization of O/W cosmetic emulsions. Cetearyl glucoside was used as a natural, biodegradable non-ionic emulsifier in the relatively low concentration (1%), and the mixture of co-emulsifiers (stearic acid, cetyl alcohol, stearyl alcohol and glyceryl stearate) was used to stabilize the formulations. MethodsTo determine the optimal composition of co-emulsifiers mixture, D-optimal mixture experimental design was used. Prepared emulsions were characterized with rheological measurements, centrifugation test, specific conductivity and pH value measurements. ResultsAll prepared samples appeared as white and homogenous creams, except for one homogenous and viscous lotion co-stabilized by stearic acid alone. Centrifugation testing revealed some phase separation only in the case of sample co-stabilized using glyceryl stearate alone. The obtained pH values indicated that all samples expressed mild acid value acceptable for cosmetic preparations. Specific conductivity values are attributed to the multiple phases O/W emulsions with high percentages of fixed water. Results of the rheological measurements have shown that the investigated samples exhibited non-Newtonian thixotropic behaviour. To determine the influence of each of the co-emulsifiers on emulsions properties, the obtained results were evaluated by the means of statistical analysis (ANOVA test). On the basis of comparison of statistical parameters for each of the studied responses, mixture reduced quadratic model was selected over the linear model implying that interactions between co-emulsifiers play the significant role in overall influence of co-emulsifiers on emulsions properties. ConclusionGlyceryl stearate was found to be the dominant co-emulsifier affecting emulsions properties. Interactions between the glyceryl stearate and other co-emulsifiers were also found to significantly influence emulsions properties. These findings are especially important as they can be used for development of the product that meets users' requirements, as represented in the study.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Cosmetic Science
dc.subjectcetearyl glucosideen
dc.subjectco-emulsifiersen
dc.subjectcomputer modellingen
dc.subjectemulsionsen
dc.subjectformulationen
dc.subjectstabilityen
dc.subjectmixture designen
dc.titleApplication of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈокић, С.; Ђуриш, Јелена; Ибрић, Светлана; Васиљевић, Драгана;
dc.citation.volume36
dc.citation.issue1
dc.citation.spage79
dc.citation.epage87
dc.citation.other36(1): 79-87
dc.citation.rankM22
dc.identifier.wos000330629500012
dc.identifier.doi10.1111/ics.12099
dc.identifier.pmid24127836
dc.identifier.scopus2-s2.0-84892435540
dc.type.versionpublishedVersion


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Приказ основних података о документу