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Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?

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2014
Authors
Dopsaj, Violeta
Martinović, Jelena
Dopsaj, Milivoj
Article (Published version)
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Abstract
Introduction: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf((R))), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes. Methods: A total of 142 athletes were divided into three groups: with iron depletion, with iron-deficient erythropoiesis, and controls. The following parameters were measured: RBCs (red blood cells), Hb (hemoglobin), Hct (hematocrit), MCV (mean cellular volume), MCH (mean cell hemoglobin), MCHC (mean cell hemoglobin corpuscular), RDW (red cell distribution width), Maf((R)), Reticulocytes, Ferritin, sTfR (soluble transferrin receptor), Transferrin, Haptoglobin, IL- 6 (Interleukin-6), hs-CRP (high-sensitivity C-reactive protein). Results: The best Maf((R)) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%. The AUC was 0.690 (CI 95% 0.607-0.765, P lt 0.001). ROC curve a...nalysis for Maf((R)) in the diagnosis of iron-deficient erythropoiesis indicates sensitivity of 61.5%, and specificity of 93.0%, with AUC=0.826 (CI 95% 0.754-0.885, P lt 0.001) and on cutoff value 114. Conclusions: This study shows that Maf((R)), generated by the Coulter LH 700 Series hematology analyzers, performs very well in discriminating healthy athletes and those with different stages of iron deficiency. Also, in cost/benefit terms, monitoring of Maf((R)) is justified as a low cost, effective screening parameter for determining iron status in athletes.

Keywords:
Iron deficiency / anemia / ferritin / exercise / transferrin saturation / athletes
Source:
International Journal of Laboratory Hematology, 2014, 36, 1, 37-44
Publisher:
  • Wiley-Blackwell, Hoboken
Funding / projects:
  • A multidisciplinary study of the role of genetic and acquired autoimmune abnormalities in the onset of systemic manifestations of antiphospholipid syndrome. (RS-175041)

DOI: 10.1111/ijlh.12115

ISSN: 1751-5521

PubMed: 23731862

WoS: 000330725400013

Scopus: 2-s2.0-84892479751
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6
6
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2171
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
AU  - Dopsaj, Milivoj
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2171
AB  - Introduction: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf((R))), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes. Methods: A total of 142 athletes were divided into three groups: with iron depletion, with iron-deficient erythropoiesis, and controls. The following parameters were measured: RBCs (red blood cells), Hb (hemoglobin), Hct (hematocrit), MCV (mean cellular volume), MCH (mean cell hemoglobin), MCHC (mean cell hemoglobin corpuscular), RDW (red cell distribution width), Maf((R)), Reticulocytes, Ferritin, sTfR (soluble transferrin receptor), Transferrin, Haptoglobin, IL- 6 (Interleukin-6), hs-CRP (high-sensitivity C-reactive protein). Results: The best Maf((R)) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%. The AUC was 0.690 (CI 95% 0.607-0.765, P lt 0.001). ROC curve analysis for Maf((R)) in the diagnosis of iron-deficient erythropoiesis indicates sensitivity of 61.5%, and specificity of 93.0%, with AUC=0.826 (CI 95% 0.754-0.885, P lt 0.001) and on cutoff value 114. Conclusions: This study shows that Maf((R)), generated by the Coulter LH 700 Series hematology analyzers, performs very well in discriminating healthy athletes and those with different stages of iron deficiency. Also, in cost/benefit terms, monitoring of Maf((R)) is justified as a low cost, effective screening parameter for determining iron status in athletes.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Laboratory Hematology
T1  - Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?
VL  - 36
IS  - 1
SP  - 37
EP  - 44
DO  - 10.1111/ijlh.12115
ER  - 
@article{
author = "Dopsaj, Violeta and Martinović, Jelena and Dopsaj, Milivoj",
year = "2014",
abstract = "Introduction: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf((R))), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes. Methods: A total of 142 athletes were divided into three groups: with iron depletion, with iron-deficient erythropoiesis, and controls. The following parameters were measured: RBCs (red blood cells), Hb (hemoglobin), Hct (hematocrit), MCV (mean cellular volume), MCH (mean cell hemoglobin), MCHC (mean cell hemoglobin corpuscular), RDW (red cell distribution width), Maf((R)), Reticulocytes, Ferritin, sTfR (soluble transferrin receptor), Transferrin, Haptoglobin, IL- 6 (Interleukin-6), hs-CRP (high-sensitivity C-reactive protein). Results: The best Maf((R)) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%. The AUC was 0.690 (CI 95% 0.607-0.765, P lt 0.001). ROC curve analysis for Maf((R)) in the diagnosis of iron-deficient erythropoiesis indicates sensitivity of 61.5%, and specificity of 93.0%, with AUC=0.826 (CI 95% 0.754-0.885, P lt 0.001) and on cutoff value 114. Conclusions: This study shows that Maf((R)), generated by the Coulter LH 700 Series hematology analyzers, performs very well in discriminating healthy athletes and those with different stages of iron deficiency. Also, in cost/benefit terms, monitoring of Maf((R)) is justified as a low cost, effective screening parameter for determining iron status in athletes.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?",
volume = "36",
number = "1",
pages = "37-44",
doi = "10.1111/ijlh.12115"
}
Dopsaj, V., Martinović, J.,& Dopsaj, M.. (2014). Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 36(1), 37-44.
https://doi.org/10.1111/ijlh.12115
Dopsaj V, Martinović J, Dopsaj M. Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?. in International Journal of Laboratory Hematology. 2014;36(1):37-44.
doi:10.1111/ijlh.12115 .
Dopsaj, Violeta, Martinović, Jelena, Dopsaj, Milivoj, "Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?" in International Journal of Laboratory Hematology, 36, no. 1 (2014):37-44,
https://doi.org/10.1111/ijlh.12115 . .

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