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Two copies of bla (NDM-1) gene are present in NDM-1 producing Pseudomonas aeruginosa isolates from Serbia

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2014
Authors
Jovčić, Branko
Lepsanović, Zorica
Begović, Jelena
Filipić, Brankica
Kojić, Milan
Article (Published version)
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Abstract
New Delhi metallo-beta-lactamase producing Pseudomonas aeruginosa isolates are of special interest since P. aeruginosa is a major cause of nosocomial infections, the treatment of which could now be jeopardized, especially in developing countries. Six additional NDM-1 positive P. aeruginosa clinical isolates belonging to two different genotypes were shown to be plasmid-free. PFGE-hybridization experiments revealed the chromosomal location of the bla (NDM-1) gene. Restriction analysis and hybridization revealed that two copies of the bla (NDM-1) gene are present in the genomes of all tested isolates, as in previously characterized P. aeruginosa MMA83. Moreover, it was shown that increasing imipenem concentration did not have the effect on copy number of the bla (NDM-1) gene in the genome of P. aeruginosa MMA83.
Keywords:
NDM-1 / Metallo-beta-lactamase / Molecular genetics / Pseudomonas aeruginosa
Source:
Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 2014, 105, 3, 613-618
Publisher:
  • Springer, Dordrecht
Projects:
  • Genes and molecular mechanisms promoting probiotic activity of lactic acid bacteria from Western Balkan (RS-173019)

DOI: 10.1007/s10482-013-0094-z

ISSN: 0003-6072

PubMed: 24343100

WoS: 000330953700018

Scopus: 2-s2.0-84894254640
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2173
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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