Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach
Authorized Users Only
2014
Authors
Golubović, BojanaVučićević, Katarina

Radivojević, Dragana
Vezmar-Kovačević, Sandra

Prostran, Milica

Miljković, Branislava

Article (Published version)

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Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic and clinical factors on tacrolimus clearance was evaluated. Following the initiation of treatment with tacrolimus, the results of our study indicate a decrease of the drug clearance on day 15, 1 and 6 months after transplantation for 4.4%, 6.3% and 10.92%, respectively. Our model suggests a negative correlation between tacrolimus clearance and haematocrit. According to final model, clearance decreases with increasing of aspartate aminotransferase. Our results demonstrated that CL/F increases with patients' weight. This study reveals incensement for 10.4% in tacrolimus clearance with alteration of patients' minimal measured total protein levels to upper normal range. The findings of this study explore various factors of tacrolimus pharmacokinetic variability and p...oint out a relationship between tacrolimus clearance and total plasma protein. Developed model demonstrates the feasibility of estimation of individual tacrolimus clearance and may allow rational individualization of tacrolimus dosing in kidney transplant patients.
Keywords:
Kidney transplantation / Plasma proteins / Population pharmacokinetics / Tacrolimus / Therapeutic monitoringSource:
European Journal of Pharmaceutical Sciences, 2014, 52, 34-40Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.ejps.2013.10.008
ISSN: 0928-0987
PubMed: 24184751
WoS: 000331022100005
Scopus: 2-s2.0-84887585346
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PharmacyTY - JOUR AU - Golubović, Bojana AU - Vučićević, Katarina AU - Radivojević, Dragana AU - Vezmar-Kovačević, Sandra AU - Prostran, Milica AU - Miljković, Branislava PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2174 AB - Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic and clinical factors on tacrolimus clearance was evaluated. Following the initiation of treatment with tacrolimus, the results of our study indicate a decrease of the drug clearance on day 15, 1 and 6 months after transplantation for 4.4%, 6.3% and 10.92%, respectively. Our model suggests a negative correlation between tacrolimus clearance and haematocrit. According to final model, clearance decreases with increasing of aspartate aminotransferase. Our results demonstrated that CL/F increases with patients' weight. This study reveals incensement for 10.4% in tacrolimus clearance with alteration of patients' minimal measured total protein levels to upper normal range. The findings of this study explore various factors of tacrolimus pharmacokinetic variability and point out a relationship between tacrolimus clearance and total plasma protein. Developed model demonstrates the feasibility of estimation of individual tacrolimus clearance and may allow rational individualization of tacrolimus dosing in kidney transplant patients. PB - Elsevier Science BV, Amsterdam T2 - European Journal of Pharmaceutical Sciences T1 - Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach VL - 52 SP - 34 EP - 40 DO - 10.1016/j.ejps.2013.10.008 ER -
@article{ author = "Golubović, Bojana and Vučićević, Katarina and Radivojević, Dragana and Vezmar-Kovačević, Sandra and Prostran, Milica and Miljković, Branislava", year = "2014", abstract = "Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic and clinical factors on tacrolimus clearance was evaluated. Following the initiation of treatment with tacrolimus, the results of our study indicate a decrease of the drug clearance on day 15, 1 and 6 months after transplantation for 4.4%, 6.3% and 10.92%, respectively. Our model suggests a negative correlation between tacrolimus clearance and haematocrit. According to final model, clearance decreases with increasing of aspartate aminotransferase. Our results demonstrated that CL/F increases with patients' weight. This study reveals incensement for 10.4% in tacrolimus clearance with alteration of patients' minimal measured total protein levels to upper normal range. The findings of this study explore various factors of tacrolimus pharmacokinetic variability and point out a relationship between tacrolimus clearance and total plasma protein. Developed model demonstrates the feasibility of estimation of individual tacrolimus clearance and may allow rational individualization of tacrolimus dosing in kidney transplant patients.", publisher = "Elsevier Science BV, Amsterdam", journal = "European Journal of Pharmaceutical Sciences", title = "Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach", volume = "52", pages = "34-40", doi = "10.1016/j.ejps.2013.10.008" }
Golubović, B., Vučićević, K., Radivojević, D., Vezmar-Kovačević, S., Prostran, M.,& Miljković, B.. (2014). Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach. in European Journal of Pharmaceutical Sciences Elsevier Science BV, Amsterdam., 52, 34-40. https://doi.org/10.1016/j.ejps.2013.10.008
Golubović B, Vučićević K, Radivojević D, Vezmar-Kovačević S, Prostran M, Miljković B. Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach. in European Journal of Pharmaceutical Sciences. 2014;52:34-40. doi:10.1016/j.ejps.2013.10.008 .
Golubović, Bojana, Vučićević, Katarina, Radivojević, Dragana, Vezmar-Kovačević, Sandra, Prostran, Milica, Miljković, Branislava, "Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach" in European Journal of Pharmaceutical Sciences, 52 (2014):34-40, https://doi.org/10.1016/j.ejps.2013.10.008 . .