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dc.creatorGolubović, Bojana
dc.creatorVučićević, Katarina
dc.creatorRadivojević, Dragana
dc.creatorVezmar-Kovačević, Sandra
dc.creatorProstran, Milica
dc.creatorMiljković, Branislava
dc.date.accessioned2019-09-02T11:40:54Z
dc.date.available2019-09-02T11:40:54Z
dc.date.issued2014
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2174
dc.description.abstractData from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic and clinical factors on tacrolimus clearance was evaluated. Following the initiation of treatment with tacrolimus, the results of our study indicate a decrease of the drug clearance on day 15, 1 and 6 months after transplantation for 4.4%, 6.3% and 10.92%, respectively. Our model suggests a negative correlation between tacrolimus clearance and haematocrit. According to final model, clearance decreases with increasing of aspartate aminotransferase. Our results demonstrated that CL/F increases with patients' weight. This study reveals incensement for 10.4% in tacrolimus clearance with alteration of patients' minimal measured total protein levels to upper normal range. The findings of this study explore various factors of tacrolimus pharmacokinetic variability and point out a relationship between tacrolimus clearance and total plasma protein. Developed model demonstrates the feasibility of estimation of individual tacrolimus clearance and may allow rational individualization of tacrolimus dosing in kidney transplant patients.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectKidney transplantationen
dc.subjectPlasma proteinsen
dc.subjectPopulation pharmacokineticsen
dc.subjectTacrolimusen
dc.subjectTherapeutic monitoringen
dc.titleTotal plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approachen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиљковић, Бранислава; Радивојевић, Драгана; Голубовић, Бојана; Простран, Милица; Вучићевић, Катарина; Везмар-Ковачевић, Сандра;
dc.citation.volume52
dc.citation.spage34
dc.citation.epage40
dc.citation.other52: 34-40
dc.citation.rankM21
dc.identifier.wos000331022100005
dc.identifier.doi10.1016/j.ejps.2013.10.008
dc.identifier.pmid24184751
dc.identifier.scopus2-s2.0-84887585346
dc.identifier.rcubconv_3021
dc.type.versionpublishedVersion


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