Приказ основних података о документу
Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods
dc.creator | Pantelić, Ivana | |
dc.creator | Lukić, Milica | |
dc.creator | Marković, Bojan | |
dc.creator | Daniels, Rolf | |
dc.creator | Vesić, Sonja | |
dc.creator | Vuleta, Gordana | |
dc.creator | Savić, Snežana | |
dc.date.accessioned | 2019-09-02T11:40:56Z | |
dc.date.available | 2019-09-02T11:40:56Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1083-7450 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2177 | |
dc.description.abstract | Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Pharmaceutical Development and Technology | |
dc.subject | Alkyl polyglucosides | en |
dc.subject | penetration enhancers | en |
dc.subject | skin blanching assay | en |
dc.subject | skin hydration | en |
dc.subject | skin stripping | en |
dc.title | Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вулета, Гордана; Лукић, Милица; Весић, Соња; Савић, Снежана; Марковић, Бојан; Даниелс, Ролф; Пантелић, Ивана; | |
dc.citation.volume | 19 | |
dc.citation.issue | 1 | |
dc.citation.spage | 55 | |
dc.citation.epage | 64 | |
dc.citation.other | 19(1): 55-64 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000328132200007 | |
dc.identifier.doi | 10.3109/10837450.2012.751407 | |
dc.identifier.pmid | 23259632 | |
dc.identifier.scopus | 2-s2.0-84899963035 | |
dc.type.version | publishedVersion |