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dc.creatorMašić, Ivana
dc.creatorIlić, Ilija
dc.creatorDreu, Rok
dc.creatorIbrić, Svetlana
dc.creatorParojčić, Jelena
dc.creatorSrcić, Stanko
dc.date.accessioned2019-09-02T11:41:01Z
dc.date.available2019-09-02T11:41:01Z
dc.date.issued2014
dc.identifier.issn0363-9045
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2179
dc.description.abstractObjective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.en
dc.publisherInforma Healthcare, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceDrug Development and Industrial Pharmacy
dc.subjectBinder addition procedureen
dc.subjectfluid beden
dc.subjectgrowth mechanismen
dc.subjecthot melten
dc.subjectspray-onen
dc.titleMelt granulation in fluidized bed: a comparative study of spray-on versus in situ procedureen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПаројчић, Јелена; Машић, Ивана; Срцић, Станко; Илић, Илија; Дреу, Рок; Ибрић, Светлана;
dc.citation.volume40
dc.citation.issue1
dc.citation.spage23
dc.citation.epage32
dc.citation.other40(1): 23-32
dc.citation.rankM22
dc.identifier.wos000328199300004
dc.identifier.doi10.3109/03639045.2012.744415
dc.identifier.pmid23294368
dc.identifier.scopus2-s2.0-84890545646
dc.identifier.rcubconv_2980
dc.type.versionpublishedVersion


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