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dc.creatorArsenović-Ranin, Nevena
dc.creatorKosec, Duško
dc.creatorPilipović, Ivan
dc.creatorBufan, Biljana
dc.creatorStojić-Vukanić, Zorica
dc.creatorRadojević, Katarina
dc.creatorNacka-Aleksić, Mirjana
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:41:19Z
dc.date.available2019-09-02T11:41:19Z
dc.date.issued2014
dc.identifier.issn1021-7401
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2190
dc.description.abstractObjective: Considering a causal role of androgens in thymic involution, age-related remodeling of peripheral T-cell compartments in the absence of testicular hormones was evaluated. Methods: Rats were orchidectomized (ORX) at the age of 1 month, and T-peripheral blood lymphocytes (PBLs) and splenocytes from young (75-day-old) and aged (24-month-old) rats were examined for differentiation/activation and immunoregulatory marker expression. Results: In ORX rats, following the initial rise, the counts of CD4+ and CD8+ PBLs diminished with aging. This reflected the decline in thymic export as shown by recent thymic emigrant (RTE) enumeration. Orchidectomy increased the count of both of the major T-splenocyte subsets in young rats, and they (differently from controls) remained stable with aging. The CD4+:CD8+ T-splenocyte ratio in ORX rats shifted towards CD4+ cells compared to age-matched controls. Although in the major T-cell subsets in the blood and spleen from aged ORX rats the numbers of RTEs were comparable to the corresponding values in age-matched controls, the numbers of mature naive and memory/activated cells substantially differed. Compared with age-matched controls, in aged ORX rats the numbers of CD4+ mature naive PBLs and splenocytes were reduced, whereas those of CD4+ memory/activated cells (predictive of early mortality) were increased. Additionally, in spleens from aged ORX rats, despite unaltered thymic export, CD4+CD25+FoxP3+ and natural killer T cell counts were greater than in age-matched controls. Conclusion: (i) Age-related decline in thymopoietic efficacy is not dependent on androgen presence, and (ii) androgens are involved in the maintenance of peripheral T-cell (particularly CD4+ cell) homeostasis during aging.en
dc.publisherKarger, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceNeuroImmunoModulation
dc.subjectAgingen
dc.subjectAndrogen deprivationen
dc.subjectRecent thymic emigrantsen
dc.subjectNaive CD4+lymphocytesen
dc.subjectT regulatory cellsen
dc.subjectNatural killer T cellsen
dc.titleAndrogens Contribute to Age-Associated Changes in Peripheral T-Cell Homeostasis Acting in a Thymus-Independent Wayen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрсеновић-Ранин, Невена; Пилиповић, Иван; Косец, Душко; Лепосавић, Гордана; Стојић-Вуканић, Зорица; Буфан, Биљана; Радојевић, Катарина; Нацка-Aлексић, Мирјана;
dc.citation.volume21
dc.citation.issue4
dc.citation.spage161
dc.citation.epage182
dc.citation.other21(4): 161-182
dc.citation.rankM23
dc.identifier.wos000331774300001
dc.identifier.doi10.1159/000355349
dc.identifier.pmid24504059
dc.identifier.scopus2-s2.0-84893693052
dc.identifier.rcubconv_3024
dc.type.versionpublishedVersion


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