Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance
Samo za registrovane korisnike
2014
Autori
Pantelić, IvanaLukić, Milica
Marković, Bojan
Lusiana
Hoffmann, Christine
Mueller-Goymann, Christel
Milić, Jela
Daniels, Rolf
Savić, Snežana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation...) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.
Ključne reči:
Alkyl polyglucosides / artificial skin constructs / Franz diffusion cells / isolated stratum corneum / tape strippingIzvor:
Drug Development and Industrial Pharmacy, 2014, 40, 7, 960-971Izdavač:
- Informa Healthcare, London
Finansiranje / projekti:
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-MESTD-Technological Development (TD or TR)-34031)
DOI: 10.3109/03639045.2013.794827
ISSN: 0363-9045
PubMed: 23688275
WoS: 000337085500015
Scopus: 2-s2.0-84902279125
Institucija/grupa
PharmacyTY - JOUR AU - Pantelić, Ivana AU - Lukić, Milica AU - Marković, Bojan AU - Lusiana AU - Hoffmann, Christine AU - Mueller-Goymann, Christel AU - Milić, Jela AU - Daniels, Rolf AU - Savić, Snežana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2194 AB - Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability. PB - Informa Healthcare, London T2 - Drug Development and Industrial Pharmacy T1 - Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance VL - 40 IS - 7 SP - 960 EP - 971 DO - 10.3109/03639045.2013.794827 ER -
@article{ author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Lusiana and Hoffmann, Christine and Mueller-Goymann, Christel and Milić, Jela and Daniels, Rolf and Savić, Snežana", year = "2014", abstract = "Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.", publisher = "Informa Healthcare, London", journal = "Drug Development and Industrial Pharmacy", title = "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance", volume = "40", number = "7", pages = "960-971", doi = "10.3109/03639045.2013.794827" }
Pantelić, I., Lukić, M., Marković, B., Lusiana, Hoffmann, C., Mueller-Goymann, C., Milić, J., Daniels, R.,& Savić, S.. (2014). Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy Informa Healthcare, London., 40(7), 960-971. https://doi.org/10.3109/03639045.2013.794827
Pantelić I, Lukić M, Marković B, Lusiana, Hoffmann C, Mueller-Goymann C, Milić J, Daniels R, Savić S. Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy. 2014;40(7):960-971. doi:10.3109/03639045.2013.794827 .
Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Lusiana, Hoffmann, Christine, Mueller-Goymann, Christel, Milić, Jela, Daniels, Rolf, Savić, Snežana, "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance" in Drug Development and Industrial Pharmacy, 40, no. 7 (2014):960-971, https://doi.org/10.3109/03639045.2013.794827 . .