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Oxidative status parameters in children with urinary tract infection

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2014
2193.pdf (102.7Kb)
Authors
Petrović, Stanislava
Bogavac-Stanojević, Nataša
Kotur-Stevuljević, Jelena
Peco-Antić, Amira
Ivanišević, Ivana
Ivanišević, Jasmina
Paripović, Dušan
Jelić-Ivanović, Zorana
Article (Published version)
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Abstract
Introduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration... of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.

Keywords:
oxidative stress / inflammation / acute kidney injury
Source:
Biochemia Medica, 2014, 24, 2, 266-272
Publisher:
  • Croatian Soc Medical Biochemists, Zagreb
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.11613/BM.2014.029

ISSN: 1330-0962

PubMed: 24969920

WoS: 000337218300009

Scopus: 2-s2.0-84902209710
[ Google Scholar ]
4
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2195
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Petrović, Stanislava
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Ivanišević, Jasmina
AU  - Paripović, Dušan
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2195
AB  - Introduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Oxidative status parameters in children with urinary tract infection
VL  - 24
IS  - 2
SP  - 266
EP  - 272
DO  - 10.11613/BM.2014.029
ER  - 
@article{
author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Peco-Antić, Amira and Ivanišević, Ivana and Ivanišević, Jasmina and Paripović, Dušan and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Introduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Oxidative status parameters in children with urinary tract infection",
volume = "24",
number = "2",
pages = "266-272",
doi = "10.11613/BM.2014.029"
}
Petrović, S., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Peco-Antić, A., Ivanišević, I., Ivanišević, J., Paripović, D.,& Jelić-Ivanović, Z.. (2014). Oxidative status parameters in children with urinary tract infection. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 24(2), 266-272.
https://doi.org/10.11613/BM.2014.029
Petrović S, Bogavac-Stanojević N, Kotur-Stevuljević J, Peco-Antić A, Ivanišević I, Ivanišević J, Paripović D, Jelić-Ivanović Z. Oxidative status parameters in children with urinary tract infection. in Biochemia Medica. 2014;24(2):266-272.
doi:10.11613/BM.2014.029 .
Petrović, Stanislava, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Peco-Antić, Amira, Ivanišević, Ivana, Ivanišević, Jasmina, Paripović, Dušan, Jelić-Ivanović, Zorana, "Oxidative status parameters in children with urinary tract infection" in Biochemia Medica, 24, no. 2 (2014):266-272,
https://doi.org/10.11613/BM.2014.029 . .

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