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dc.creatorPetrović, Stanislava
dc.creatorBogavac-Stanojević, Nataša
dc.creatorKotur-Stevuljević, Jelena
dc.creatorPeco-Antić, Amira
dc.creatorIvanišević, Ivana
dc.creatorIvanišević, Jasmina
dc.creatorParipović, Dušan
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:41:26Z
dc.date.available2019-09-02T11:41:26Z
dc.date.issued2014
dc.identifier.issn1330-0962
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2195
dc.description.abstractIntroduction: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acute kidney injury (AKI) development. Materials and methods: The patients enrolled in the study comprised 50 Caucasian children (median age was 6 months) with UTI. Total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), inflammation marker C-reactive protein (CRP) and renal function parameters urea and creatinine were analyzed in patient's serums. Results: According to duration of inflammation during UTI, TAS values were significantly higher (0.99 vs. 0.58 mmol/L, P = 0.017) and OSI values were significantly lower (0.032 vs. 0.041 AU, P = 0.037) in the subjects with longer duration of inflammation than in the subjects with shorter duration of inflammation. We did not find significant difference in basal values of oxidative status parameters according to AKI development. Conclusions: OSI values could detect the simultaneous change of TAS and TOS due to change in the oxidative-antioxidant balance during the recovery of children with UTI. TAS and OSI as markers of oxidative stress during UTI are sensitive to accompanying inflammatory condition. Further investigations are needed to evaluate whether TAS, TOS and OSI could be used to monitor disease severity in children with UTI.en
dc.publisherCroatian Soc Medical Biochemists, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceBiochemia Medica
dc.subjectoxidative stressen
dc.subjectinflammationen
dc.subjectacute kidney injuryen
dc.titleOxidative status parameters in children with urinary tract infectionen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЈелић-Ивановић, Зорана; Париповић, Душан; Иванишевић, Ивана; Котур-Стевуљевић, Јелена; Петровић, Станислава; Богавац-Станојевић, Наташа; Пецо-Aнтић, Aмира; Иванишевић, Јасмина;
dc.citation.volume24
dc.citation.issue2
dc.citation.spage266
dc.citation.epage272
dc.citation.other24(2): 266-272
dc.citation.rankM21
dc.identifier.wos000337218300009
dc.identifier.doi10.11613/BM.2014.029
dc.identifier.pmid24969920
dc.identifier.scopus2-s2.0-84902209710
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/922/2193.pdf
dc.type.versionpublishedVersion


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