Приказ основних података о документу

dc.creatorJovanović, MS
dc.creatorBrborić, Jasmina
dc.creatorVladimirov, S
dc.creatorZmbova, B
dc.creatorVuksanović, LJ
dc.creatorŽivanov-Stakić, Dobrila
dc.creatorObradović, V
dc.date.accessioned2019-09-02T10:51:29Z
dc.date.available2019-09-02T10:51:29Z
dc.date.issued1999
dc.identifier.issn0236-5731
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/219
dc.description.abstractA new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.en
dc.publisherSpringer
dc.publisherElsevier Science B. V., Amsterdam
dc.rightsrestrictedAccess
dc.sourceJournal of Radioanalytical and Nuclear Chemistry
dc.titleNew Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imagingen
dc.typecontributionToPeriodical
dc.rights.licenseARR
dcterms.abstractЈовановић, МС; Брборић, Јасмина; Владимиров, С; Живанов-Стакић, Добрила; Змбова, Б; Вуксановић, ЛЈ; Обрадовић, В;
dc.citation.volume240
dc.citation.issue1
dc.citation.spage321
dc.citation.epage324
dc.citation.other240(1): 321-324
dc.citation.rankM21
dc.identifier.wos000080027500044
dc.identifier.doi10.1007/BF02349171
dc.identifier.scopus2-s2.0-0032960102
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу