Show simple item record

dc.creatorStevanović, Dejan
dc.creatorTadić, Ivana
dc.creatorKnez, Rajna
dc.date.accessioned2019-09-02T11:41:41Z
dc.date.available2019-09-02T11:41:41Z
dc.date.issued2014
dc.identifier.issn1092-8529
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2203
dc.description.abstractThere is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and adolescents with depressive or anxiety disorders. A comprehensive search resulted in 5 clinical trials to be included in this review: 4 trials with major depressive disorder (MDD) and 1 trial with social anxiety disorder (SAD). In one MDD trial, fluoxetine combined with cognitive behavior therapy (CBT) significantly improved QOL compared to fluoxetine or CBT alone (effect sizes were 0.53 and 0.69, respectively). In 2 combined trials, sertraline alone significantly improved QOL among adolescents with MDD (effect size was 0.29), but not among children with MDD. Essentially, it was observed that antidepressants in these trials had minor positive effects on QOL improvement, which were lower than their potential to improve depressive symptoms. Although fluoxetine with CBT or sertraline monotherapy were shown to have some potential to improve QOL, this systematic review found inconclusive evidence that antidepressant treatments improve QOL among children and adolescents with depressive or anxiety disorders. More research is required, considering that QOL is currently under-evaluated in clinical trials with antidepressants among children and adolescents and available trials have limited methodological quality when reporting QOL data.en
dc.publisherCambridge Univ Press, New York
dc.rightsrestrictedAccess
dc.sourceCNS Spectrums
dc.subjectAnxiety disordersen
dc.subjectclinical trialen
dc.subjectdepressionen
dc.subjectefficacyen
dc.subjectquality of lifeen
dc.titleAre antidepressants effective in quality of life improvement among children and adolescents? A systematic reviewen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтевановић, Дејан; Кнез, Рајна; Тадић, Ивана;
dc.citation.volume19
dc.citation.issue2
dc.citation.spage134
dc.citation.epage141
dc.citation.other19(2): 134-141
dc.citation.rankM22
dc.identifier.wos000337748000006
dc.identifier.doi10.1017/S1092852913000576
dc.identifier.pmid24029410
dc.identifier.scopus2-s2.0-84901711943
dc.identifier.rcubconv_3107
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record