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dc.creatorShenger, Musbah Salem Mohamed
dc.creatorFilipić, Slavica
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:41:45Z
dc.date.available2019-09-02T11:41:45Z
dc.date.issued2014
dc.identifier.issn1082-6076
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2207
dc.description.abstractThe chromatographic behavior of 16 alpha adrenergic and imidazoline receptor ligands has been studied by reversed-phase thin-layer chromatography (RP-TLC) on RP-18 and CN stationary phases. Retention constant R-M(0) was determined for all tested compounds in three different chromatographic systems: methanol-water/RP-18, tetrahydrofuran-ammonia-water/RP-18, and tetrahydrofuran-ammonia-water/CN. Good correlations between determined hydrophobic parameters R-M(0) and calculated log P values were obtained for the system tetrahydrofuran-ammonia-water on both RP-18 and CN stationary phases. Experimentally obtained R-M(0) values and computed molecular parameters of the examined compounds were further used for the quantitative structure-retention relationship (QSRR) study, in order to determine the most important properties governing retention. The QSRR modeling was performed with use of the partial least squares regression, and predictive performances of the developed QSRR models were tested by use of the cross-validation and external test set prediction. The created models revealed that apart from lipophilicity, constitutional descriptors, the amount of van der Waals surface area having a property P (P_VSA-like descriptors), and hydrogen bonding properties of the tested compounds were important for the retention behavior in the RP-TLC systems.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectguanidine derivativesen
dc.subjectimidazoline derivativesen
dc.subjectlipophilicityen
dc.subjectPLSen
dc.subjectQSRRen
dc.subjectRP-TLCen
dc.titleEstimation of lipophilicity and retention behavior of some alpha adrenergic and imidazoline receptor ligands using rp-tlcen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСхенгер, Мусбах Салем Мохамед; Aгбаба, Даница; Филипић, Славица; Николић, Катарина;
dc.citation.volume37
dc.citation.issue20
dc.citation.spage2829
dc.citation.epage2845
dc.citation.other37(20): 2829-2845
dc.citation.rankM23
dc.identifier.wos000337971200003
dc.identifier.doi10.1080/10739149.2014.906880
dc.identifier.scopus2-s2.0-84903189900
dc.identifier.rcubconv_3111
dc.type.versionpublishedVersion


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