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Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus

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2014
2207.pdf (472.5Kb)
Authors
Božić, Dragana
Milenković, Marina
Ivković, Branka
Cirković, Ivana
Article (Published version)
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Abstract
Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds r...educed the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.

Keywords:
chalcones / glycocalyx / biofilms / MRSA
Source:
Brazilian Journal of Microbiology, 2014, 45, 1, 263-270
Publisher:
  • Soc Brasileira Microbiologia, Sao Paulo
Funding / projects:
  • Antibiotic resistant bacterial pathogens in Serbia: phenotypic and genotypic characterization (RS-175039)

DOI: 10.1590/S1517-83822014000100038

ISSN: 1517-8382

PubMed: 24948943

WoS: 000338109800038

Scopus: 2-s2.0-84901921016
[ Google Scholar ]
18
13
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2209
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Ivković, Branka
AU  - Cirković, Ivana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2209
AB  - Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds reduced the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.
PB  - Soc Brasileira Microbiologia, Sao Paulo
T2  - Brazilian Journal of Microbiology
T1  - Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus
VL  - 45
IS  - 1
SP  - 263
EP  - 270
DO  - 10.1590/S1517-83822014000100038
ER  - 
@article{
author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Cirković, Ivana",
year = "2014",
abstract = "Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds reduced the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.",
publisher = "Soc Brasileira Microbiologia, Sao Paulo",
journal = "Brazilian Journal of Microbiology",
title = "Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus",
volume = "45",
number = "1",
pages = "263-270",
doi = "10.1590/S1517-83822014000100038"
}
Božić, D., Milenković, M., Ivković, B.,& Cirković, I.. (2014). Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus. in Brazilian Journal of Microbiology
Soc Brasileira Microbiologia, Sao Paulo., 45(1), 263-270.
https://doi.org/10.1590/S1517-83822014000100038
Božić D, Milenković M, Ivković B, Cirković I. Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus. in Brazilian Journal of Microbiology. 2014;45(1):263-270.
doi:10.1590/S1517-83822014000100038 .
Božić, Dragana, Milenković, Marina, Ivković, Branka, Cirković, Ivana, "Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus" in Brazilian Journal of Microbiology, 45, no. 1 (2014):263-270,
https://doi.org/10.1590/S1517-83822014000100038 . .

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