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dc.creatorBožić, Dragana
dc.creatorMilenković, Marina
dc.creatorIvković, Branka
dc.creatorCirković, Ivana
dc.date.accessioned2019-09-02T11:41:50Z
dc.date.available2019-09-02T11:41:50Z
dc.date.issued2014
dc.identifier.issn1517-8382
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2209
dc.description.abstractBiofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds reduced the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.en
dc.publisherSoc Brasileira Microbiologia, Sao Paulo
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175039/RS//
dc.rightsopenAccess
dc.sourceBrazilian Journal of Microbiology
dc.subjectchalconesen
dc.subjectglycocalyxen
dc.subjectbiofilmsen
dc.subjectMRSAen
dc.titleNewly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureusen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractМиленковић, Марина; Божић, Драгана; Цирковић, Ивана; Ивковић, Бранка;
dc.citation.volume45
dc.citation.issue1
dc.citation.spage263
dc.citation.epage270
dc.citation.other45(1): 263-270
dc.citation.rankM23
dc.identifier.wos000338109800038
dc.identifier.doi10.1590/S1517-83822014000100038
dc.identifier.pmid24948943
dc.identifier.scopus2-s2.0-84901921016
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/933/2207.pdf
dc.identifier.rcubconv_3113
dc.type.versionpublishedVersion


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