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dc.creatorCvijić, Sandra
dc.creatorParojčić, Jelena
dc.creatorLangguth, Peter
dc.date.accessioned2019-09-02T11:41:51Z
dc.date.available2019-09-02T11:41:51Z
dc.date.issued2014
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2210
dc.description.abstractConcomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence of food is one of the key factors limiting oral absorption of drugs with limited permeability and absorption restricted to the upper parts of the intestine, while having negligible effect on pharmacokinetic profile of drugs with pH- and site-independent absorption. Dissolution medium pH 4.6 with the addition of hydroxypropyl methylcellulose was suggested to simulate postprandial gastric conditions for drugs whose solubility under these conditions is not the limiting factor for drug absorption. In addition, drug formulation was found to be an interfering factor in relation to the impact of medium viscosity on the rate and extent of drug absorption.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectFood effecten
dc.subjectViscosityen
dc.subjectDisintegrationen
dc.subjectDissolutionen
dc.subjectPoorly-permeable drugsen
dc.subjectAbsorption simulationen
dc.titleViscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verificationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦвијић, Сандра; Ланггутх, Петер; Паројчић, Јелена;
dc.citation.volume61
dc.citation.spage40
dc.citation.epage53
dc.citation.other61: 40-53
dc.citation.rankM21
dc.identifier.wos000338597800007
dc.identifier.doi10.1016/j.ejps.2014.04.008
dc.identifier.pmid24751672
dc.identifier.scopus2-s2.0-84902543492
dc.identifier.rcubconv_3119
dc.type.versionpublishedVersion


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