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Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.

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2014
Authors
Živković, Jelena
Barreira, Joao C. M.
Stojković, Dejan
Cebović, Tatjana
Santos-Buelga, Celestino
Maksimović, Zoran
Ferreira, Isabel C. F. R.
Article (Published version)
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Abstract
The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significa...nt extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects.

Keywords:
Veronica urticifolia / Phenolic profile / HPLC-DAD/ESI-MS / Antibacterial / Antimutagenicity / Ehrlich carcinoma
Source:
Journal of Functional Foods, 2014, 9, 192-201
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Biotechnology in vitro - crop, medicinal and endangered plant species (RS-173015)
  • POPH-QREN

DOI: 10.1016/j.jff.2014.04.024

ISSN: 1756-4646

WoS: 000338271900021

Scopus: 2-s2.0-84902650601
[ Google Scholar ]
16
15
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2211
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Institution
Pharmacy

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