Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.
Samo za registrovane korisnike
2014
Autori
Živković, JelenaBarreira, Joao C. M.
Stojković, Dejan
Cebović, Tatjana
Santos-Buelga, Celestino
Maksimović, Zoran
Ferreira, Isabel C. F. R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significa...nt extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects.
Ključne reči:
Veronica urticifolia / Phenolic profile / HPLC-DAD/ESI-MS / Antibacterial / Antimutagenicity / Ehrlich carcinomaIzvor:
Journal of Functional Foods, 2014, 9, 192-201Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Biotehnologija in vitro - gajene, lekovite i ugrožene biljne vrste (RS-173015)
- POPH-QREN
DOI: 10.1016/j.jff.2014.04.024
ISSN: 1756-4646
WoS: 000338271900021
Scopus: 2-s2.0-84902650601
Institucija/grupa
PharmacyTY - JOUR AU - Živković, Jelena AU - Barreira, Joao C. M. AU - Stojković, Dejan AU - Cebović, Tatjana AU - Santos-Buelga, Celestino AU - Maksimović, Zoran AU - Ferreira, Isabel C. F. R. PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2211 AB - The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects. PB - Elsevier Science BV, Amsterdam T2 - Journal of Functional Foods T1 - Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. VL - 9 SP - 192 EP - 201 DO - 10.1016/j.jff.2014.04.024 ER -
@article{ author = "Živković, Jelena and Barreira, Joao C. M. and Stojković, Dejan and Cebović, Tatjana and Santos-Buelga, Celestino and Maksimović, Zoran and Ferreira, Isabel C. F. R.", year = "2014", abstract = "The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Functional Foods", title = "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.", volume = "9", pages = "192-201", doi = "10.1016/j.jff.2014.04.024" }
Živković, J., Barreira, J. C. M., Stojković, D., Cebović, T., Santos-Buelga, C., Maksimović, Z.,& Ferreira, I. C. F. R.. (2014). Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.. in Journal of Functional Foods Elsevier Science BV, Amsterdam., 9, 192-201. https://doi.org/10.1016/j.jff.2014.04.024
Živković J, Barreira JCM, Stojković D, Cebović T, Santos-Buelga C, Maksimović Z, Ferreira ICFR. Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.. in Journal of Functional Foods. 2014;9:192-201. doi:10.1016/j.jff.2014.04.024 .
Živković, Jelena, Barreira, Joao C. M., Stojković, Dejan, Cebović, Tatjana, Santos-Buelga, Celestino, Maksimović, Zoran, Ferreira, Isabel C. F. R., "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq." in Journal of Functional Foods, 9 (2014):192-201, https://doi.org/10.1016/j.jff.2014.04.024 . .