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Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.
dc.creator | Živković, Jelena | |
dc.creator | Barreira, Joao C. M. | |
dc.creator | Stojković, Dejan | |
dc.creator | Cebović, Tatjana | |
dc.creator | Santos-Buelga, Celestino | |
dc.creator | Maksimović, Zoran | |
dc.creator | Ferreira, Isabel C. F. R. | |
dc.date.accessioned | 2019-09-02T11:41:52Z | |
dc.date.available | 2019-09-02T11:41:52Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2211 | |
dc.description.abstract | The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173015/RS// | |
dc.relation | POPH-QREN | |
dc.rights | restrictedAccess | |
dc.source | Journal of Functional Foods | |
dc.subject | Veronica urticifolia | en |
dc.subject | Phenolic profile | en |
dc.subject | HPLC-DAD/ESI-MS | en |
dc.subject | Antibacterial | en |
dc.subject | Antimutagenicity | en |
dc.subject | Ehrlich carcinoma | en |
dc.title | Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Цебовић, Татјана; Стојковић, Дејан; Барреира, Јоао Ц. М.; Ферреира, Исабел Ц. Ф. Р.; Сантос-Буелга, Целестино; Живковић, Јелена; Максимовић, Зоран; | |
dc.citation.volume | 9 | |
dc.citation.spage | 192 | |
dc.citation.epage | 201 | |
dc.citation.other | 9: 192-201 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000338271900021 | |
dc.identifier.doi | 10.1016/j.jff.2014.04.024 | |
dc.identifier.scopus | 2-s2.0-84902650601 | |
dc.type.version | publishedVersion |