Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis

2014
Authors
Ćulafić, ĐorđeStulić, Miloš
Obrenović, Radmila
Miletić, Danijela
Mijac, Dragana
Stojković, Milica
Jovanović, Marija

Ćulafić, Milica

Article (Published version)

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AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and ...B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.
Keywords:
Liver cirrhosis / Cystatin C / Renal resistive indexSource:
World Journal of Microbiology & Biotechnology, 2014, 20, 21, 6573-6579Publisher:
- Baishideng Publishing Group Inc, Pleasanton
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.3748/wjg.v20.i21.6573
ISSN: 1007-9327
PubMed: 24914379
WoS: 000338513200023
Scopus: 2-s2.0-84902108875
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Institution/Community
PharmacyTY - JOUR AU - Ćulafić, Đorđe AU - Stulić, Miloš AU - Obrenović, Radmila AU - Miletić, Danijela AU - Mijac, Dragana AU - Stojković, Milica AU - Jovanović, Marija AU - Ćulafić, Milica PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2213 AB - AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis. PB - Baishideng Publishing Group Inc, Pleasanton T2 - World Journal of Microbiology & Biotechnology T1 - Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis VL - 20 IS - 21 SP - 6573 EP - 6579 DO - 10.3748/wjg.v20.i21.6573 ER -
@article{ author = "Ćulafić, Đorđe and Stulić, Miloš and Obrenović, Radmila and Miletić, Danijela and Mijac, Dragana and Stojković, Milica and Jovanović, Marija and Ćulafić, Milica", year = "2014", abstract = "AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.", publisher = "Baishideng Publishing Group Inc, Pleasanton", journal = "World Journal of Microbiology & Biotechnology", title = "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis", volume = "20", number = "21", pages = "6573-6579", doi = "10.3748/wjg.v20.i21.6573" }
Ćulafić, Đ., Stulić, M., Obrenović, R., Miletić, D., Mijac, D., Stojković, M., Jovanović, M.,& Ćulafić, M.. (2014). Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology Baishideng Publishing Group Inc, Pleasanton., 20(21), 6573-6579. https://doi.org/10.3748/wjg.v20.i21.6573
Ćulafić Đ, Stulić M, Obrenović R, Miletić D, Mijac D, Stojković M, Jovanović M, Ćulafić M. Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology. 2014;20(21):6573-6579. doi:10.3748/wjg.v20.i21.6573 .
Ćulafić, Đorđe, Stulić, Miloš, Obrenović, Radmila, Miletić, Danijela, Mijac, Dragana, Stojković, Milica, Jovanović, Marija, Ćulafić, Milica, "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis" in World Journal of Microbiology & Biotechnology, 20, no. 21 (2014):6573-6579, https://doi.org/10.3748/wjg.v20.i21.6573 . .