Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis
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2014
Аутори
Ćulafić, ĐorđeStulić, Miloš
Obrenović, Radmila
Miletić, Danijela
Mijac, Dragana
Stojković, Milica
Jovanović, Marija
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Ćulafić, Milica
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Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and ...B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.
Кључне речи:
Liver cirrhosis / Cystatin C / Renal resistive indexИзвор:
World Journal of Microbiology & Biotechnology, 2014, 20, 21, 6573-6579Издавач:
- Baishideng Publishing Group Inc, Pleasanton
Финансирање / пројекти:
- Биомаркери оштећења и дисфункције органа (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.3748/wjg.v20.i21.6573
ISSN: 1007-9327
PubMed: 24914379
WoS: 000338513200023
Scopus: 2-s2.0-84902108875
Институција/група
PharmacyTY - JOUR AU - Ćulafić, Đorđe AU - Stulić, Miloš AU - Obrenović, Radmila AU - Miletić, Danijela AU - Mijac, Dragana AU - Stojković, Milica AU - Jovanović, Marija AU - Ćulafić, Milica PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2213 AB - AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis. PB - Baishideng Publishing Group Inc, Pleasanton T2 - World Journal of Microbiology & Biotechnology T1 - Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis VL - 20 IS - 21 SP - 6573 EP - 6579 DO - 10.3748/wjg.v20.i21.6573 ER -
@article{ author = "Ćulafić, Đorđe and Stulić, Miloš and Obrenović, Radmila and Miletić, Danijela and Mijac, Dragana and Stojković, Milica and Jovanović, Marija and Ćulafić, Milica", year = "2014", abstract = "AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis.", publisher = "Baishideng Publishing Group Inc, Pleasanton", journal = "World Journal of Microbiology & Biotechnology", title = "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis", volume = "20", number = "21", pages = "6573-6579", doi = "10.3748/wjg.v20.i21.6573" }
Ćulafić, Đ., Stulić, M., Obrenović, R., Miletić, D., Mijac, D., Stojković, M., Jovanović, M.,& Ćulafić, M.. (2014). Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology Baishideng Publishing Group Inc, Pleasanton., 20(21), 6573-6579. https://doi.org/10.3748/wjg.v20.i21.6573
Ćulafić Đ, Stulić M, Obrenović R, Miletić D, Mijac D, Stojković M, Jovanović M, Ćulafić M. Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. in World Journal of Microbiology & Biotechnology. 2014;20(21):6573-6579. doi:10.3748/wjg.v20.i21.6573 .
Ćulafić, Đorđe, Stulić, Miloš, Obrenović, Radmila, Miletić, Danijela, Mijac, Dragana, Stojković, Milica, Jovanović, Marija, Ćulafić, Milica, "Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis" in World Journal of Microbiology & Biotechnology, 20, no. 21 (2014):6573-6579, https://doi.org/10.3748/wjg.v20.i21.6573 . .