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Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis
dc.creator | Ćulafić, Đorđe | |
dc.creator | Stulić, Miloš | |
dc.creator | Obrenović, Radmila | |
dc.creator | Miletić, Danijela | |
dc.creator | Mijac, Dragana | |
dc.creator | Stojković, Milica | |
dc.creator | Jovanović, Marija | |
dc.creator | Ćulafić, Milica | |
dc.date.accessioned | 2019-09-02T11:41:56Z | |
dc.date.available | 2019-09-02T11:41:56Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1007-9327 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2213 | |
dc.description.abstract | AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFR(Cr)) and cystatin C (GFR(Cys)) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (r(s) = 0.527, P lt 0.001). More patients with decreased glomerular filtration rate were identified based on GFR(Cys) than on GFR(Cr) (P lt 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P lt 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (r(s) = 0.607, P lt 0.001). Renal resistive index correlated significantly with cystatin C (r(s) = 0.283, P = 0.028) and showed a negative correlation with GFR(Cys) (r(s) = -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis. | en |
dc.publisher | Baishideng Publishing Group Inc, Pleasanton | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | openAccess | |
dc.source | World Journal of Microbiology & Biotechnology | |
dc.subject | Liver cirrhosis | en |
dc.subject | Cystatin C | en |
dc.subject | Renal resistive index | en |
dc.title | Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стојковић, Милица; Милетић, Данијела; Ћулафић, Милица; Мијац, Драгана; Обреновић, Радмила; Стулић, Милош; Ћулафић, Ђорђе; Јовановић, Марија; | |
dc.citation.volume | 20 | |
dc.citation.issue | 21 | |
dc.citation.spage | 6573 | |
dc.citation.epage | 6579 | |
dc.citation.other | 20(21): 6573-6579 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000338513200023 | |
dc.identifier.doi | 10.3748/wjg.v20.i21.6573 | |
dc.identifier.pmid | 24914379 | |
dc.identifier.scopus | 2-s2.0-84902108875 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/937/2211.pdf | |
dc.type.version | publishedVersion |