A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl
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2014
Authors
Đokić, MarijaKachrimanis, Kyriakos
Solomun, Ljiljana

Đuriš, Jelena

Vasiljević, Dragana

Ibrić, Svetlana

Article (Published version)

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The aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small chan...ges in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles.
Keywords:
Jet-milling / Spray-drying / Aerosol dispersion / Amiloride HCl / Particle sizeSource:
Powder Technology, 2014, 262, 170-176Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.powtec.2014.04.066
ISSN: 0032-5910
WoS: 000338610500020
Scopus: 2-s2.0-84899925370
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PharmacyTY - JOUR AU - Đokić, Marija AU - Kachrimanis, Kyriakos AU - Solomun, Ljiljana AU - Đuriš, Jelena AU - Vasiljević, Dragana AU - Ibrić, Svetlana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2215 AB - The aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small changes in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles. PB - Elsevier Science BV, Amsterdam T2 - Powder Technology T1 - A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl VL - 262 SP - 170 EP - 176 DO - 10.1016/j.powtec.2014.04.066 ER -
@article{ author = "Đokić, Marija and Kachrimanis, Kyriakos and Solomun, Ljiljana and Đuriš, Jelena and Vasiljević, Dragana and Ibrić, Svetlana", year = "2014", abstract = "The aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small changes in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles.", publisher = "Elsevier Science BV, Amsterdam", journal = "Powder Technology", title = "A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl", volume = "262", pages = "170-176", doi = "10.1016/j.powtec.2014.04.066" }
Đokić, M., Kachrimanis, K., Solomun, L., Đuriš, J., Vasiljević, D.,& Ibrić, S.. (2014). A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl. in Powder Technology Elsevier Science BV, Amsterdam., 262, 170-176. https://doi.org/10.1016/j.powtec.2014.04.066
Đokić M, Kachrimanis K, Solomun L, Đuriš J, Vasiljević D, Ibrić S. A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl. in Powder Technology. 2014;262:170-176. doi:10.1016/j.powtec.2014.04.066 .
Đokić, Marija, Kachrimanis, Kyriakos, Solomun, Ljiljana, Đuriš, Jelena, Vasiljević, Dragana, Ibrić, Svetlana, "A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl" in Powder Technology, 262 (2014):170-176, https://doi.org/10.1016/j.powtec.2014.04.066 . .