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dc.creatorĐokić, Marija
dc.creatorKachrimanis, Kyriakos
dc.creatorSolomun, Ljiljana
dc.creatorĐuriš, Jelena
dc.creatorVasiljević, Dragana
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:41:58Z
dc.date.available2019-09-02T11:41:58Z
dc.date.issued2014
dc.identifier.issn0032-5910
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2215
dc.description.abstractThe aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small changes in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourcePowder Technology
dc.subjectJet-millingen
dc.subjectSpray-dryingen
dc.subjectAerosol dispersionen
dc.subjectAmiloride HClen
dc.subjectParticle sizeen
dc.titleA study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HClen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКацхриманис, Кyриакос; Соломун, Љиљана; Ђокић, Марија; Ибрић, Светлана; Васиљевић, Драгана; Ђуриш, Јелена;
dc.citation.volume262
dc.citation.spage170
dc.citation.epage176
dc.citation.other262: 170-176
dc.citation.rankM21
dc.identifier.wos000338610500020
dc.identifier.doi10.1016/j.powtec.2014.04.066
dc.identifier.scopus2-s2.0-84899925370
dc.type.versionpublishedVersion


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Приказ основних података о документу