Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae)
Authors
Kundaković, Tatjana
Stanojković, Tatjana

Kolundžija, Branka
Marković, Stevan
Šukilović, Branka
Milenković, Marina

Lakušić, Branislava

Article (Published version)
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The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galicica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and beta-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 mu g/mL against S. epidermidis to 50 mu g/mL against P. aerugmosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRCS cells. The essential oil from Korab demonstrated significantly better results than the oil from Galicica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 mu g/mL, while the oil from Galicica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 mu g/mL).
Keywords:
Satureja montana ssp pisidica / Essential oil / Cytotoxicity / Antimicrobial activity / CarvacrolSource:
Natural Product Communications, 2014, 9, 4, 569-572Publisher:
- Sage Publications Inc, Thousand Oaks
Projects:
- Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)
- Biological response modifiers in physiological and pathological conditions (RS-175011)