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Cytotoxicity and Antimicrobial Activity of the Essential Oil from Satureja montana subsp pisidica (Lamiceae)

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2014
Cytotoxicity_Antimicrobial_Activity_pub_2014.pdf (952.9Kb)
Authors
Kundaković, Tatjana
Stanojković, Tatjana
Kolundžija, Branka
Marković, Stevan
Šukilović, Branka
Milenković, Marina
Lakušić, Branislava
Article (Published version)
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Abstract
The antimicrobial and cytotoxic activities of the essential oil of Satureja montana ssp. pisidica from two localities (mountains Korab and Galicica) were studied. Forty-nine components were identified in the each sample. Oxygenated monoterpene hydrocarbons were the major compounds: carvacrol, thymol, carvacrol methyl ether and beta-linalool. Both tested essential oils showed very high and similar antimicrobial activity. Minimal inhibitory concentrations ranged from 12.5 mu g/mL against S. epidermidis to 50 mu g/mL against P. aerugmosa and C. albicans. The cytotoxic effect of the essential oils was tested against MDA-MB-361, MDA-MB-453, HeLa, LS174 and MRCS cells. The essential oil from Korab demonstrated significantly better results than the oil from Galicica, particularly against HeLa and MDA-MB-453 cell lines, with IC50 values of 63.5 and 72.3 mu g/mL, while the oil from Galicica was the most active on the human epithelial cervical cancer HeLa cells (IC50 99.7 mu g/mL).
Keywords:
Satureja montana ssp pisidica / Essential oil / Cytotoxicity / Antimicrobial activity / Carvacrol
Source:
Natural Product Communications, 2014, 9, 4, 569-572
Publisher:
  • Sage Publications Inc, Thousand Oaks
Projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)
  • Biological response modifiers in physiological and pathological conditions (RS-175011)

ISSN: 1934-578X

PubMed: 24868886

WoS: 000335083500037

Scopus: 2-s2.0-84898802085
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2217
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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