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dc.creatorRakić, Tijana
dc.creatorKasagić-Vujanović, Irena
dc.creatorJovanović, Marko
dc.creatorJančić-Stojanović, Biljana
dc.creatorIvanović, Darko
dc.date.accessioned2019-09-02T11:42:14Z
dc.date.available2019-09-02T11:42:14Z
dc.date.issued2014
dc.identifier.issn0003-2719
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2223
dc.description.abstractThis paper presents the development and optimization of a liquid chromatographic method for the determination of fluconazole and its impurities by experimental design methodology. Four experimental design types were applied: two-level full factorial design, central composite design, Box-Behnken design, and three-level full factorial design. The advantages and drawbacks of each design are described and detailed statistical evaluation of mathematical models was performed. The central composite design and three-level full factorial design created significantly better models comparing to the other methods. As the central composite design requires a smaller number of experiments, its models were used for theoretical examination of experimental space. Multiobjective optimization aiming to achieve maximal separation of all investigated substances and minimal analysis duration was performed by a grid point search. The defined optimal separation was achieved on a C-18 (125mmx4mm, 5 mu m particle size) column with a mobile phase consisting of acetonitrile and water (5mM ammonium formate) (15:85, v/v); a column temperature of 25 degrees C; a flow rate of 1.2mLmin(-1); and a detection wavelength of 260nm.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceAnalytical Letters
dc.subjectChemometricsen
dc.subjectExperimental designen
dc.subjectFluconazoleen
dc.subjectImpuritiesen
dc.subjectLiquid chromatographyen
dc.titleComparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКасагић-Вујановић, Ирена; Јанчић-Стојановић, Биљана; Ивановић, Дарко; Јовановић, Марко; Ракић, Тијана;
dc.citation.volume47
dc.citation.issue8
dc.citation.spage1334
dc.citation.epage1347
dc.citation.other47(8): 1334-1347
dc.citation.rankM23
dc.identifier.wos000335214700005
dc.identifier.doi10.1080/00032719.2013.867503
dc.identifier.scopus2-s2.0-84899735672
dc.identifier.rcubconv_3080
dc.type.versionpublishedVersion


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