Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis

2014
Authors
Bojić, SuzanaKotur-Stevuljević, Jelena

Kalezić, Nevena
Jelić-Ivanović, Zorana

Stefanović, Aleksandra

Palibrk, Ivan
Memon, Lidija

Kalaba, Zdravko
Stojanović, Marina
Simić-Ogrizović, Sanja

Article (Published version)
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Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Corr...elation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.
Source:
Disease Markers, 2014Publisher:
- Hindawi Ltd, London
Funding / projects:
DOI: 10.1155/2014/427378
ISSN: 0278-0240
PubMed: 24665146
WoS: 000331741900001
Scopus: 2-s2.0-84896936449
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PharmacyTY - JOUR AU - Bojić, Suzana AU - Kotur-Stevuljević, Jelena AU - Kalezić, Nevena AU - Jelić-Ivanović, Zorana AU - Stefanović, Aleksandra AU - Palibrk, Ivan AU - Memon, Lidija AU - Kalaba, Zdravko AU - Stojanović, Marina AU - Simić-Ogrizović, Sanja PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2226 AB - Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis. PB - Hindawi Ltd, London T2 - Disease Markers T1 - Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis DO - 10.1155/2014/427378 ER -
@article{ author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Kalezić, Nevena and Jelić-Ivanović, Zorana and Stefanović, Aleksandra and Palibrk, Ivan and Memon, Lidija and Kalaba, Zdravko and Stojanović, Marina and Simić-Ogrizović, Sanja", year = "2014", abstract = "Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.", publisher = "Hindawi Ltd, London", journal = "Disease Markers", title = "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis", doi = "10.1155/2014/427378" }
Bojić, S., Kotur-Stevuljević, J., Kalezić, N., Jelić-Ivanović, Z., Stefanović, A., Palibrk, I., Memon, L., Kalaba, Z., Stojanović, M.,& Simić-Ogrizović, S.. (2014). Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers Hindawi Ltd, London.. https://doi.org/10.1155/2014/427378
Bojić S, Kotur-Stevuljević J, Kalezić N, Jelić-Ivanović Z, Stefanović A, Palibrk I, Memon L, Kalaba Z, Stojanović M, Simić-Ogrizović S. Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers. 2014;. doi:10.1155/2014/427378 .
Bojić, Suzana, Kotur-Stevuljević, Jelena, Kalezić, Nevena, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, Palibrk, Ivan, Memon, Lidija, Kalaba, Zdravko, Stojanović, Marina, Simić-Ogrizović, Sanja, "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis" in Disease Markers (2014), https://doi.org/10.1155/2014/427378 . .