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dc.creatorKostić, Nada
dc.creatorDotsikas, Yannis
dc.creatorMalenović, Anđelija
dc.date.accessioned2019-09-02T11:42:22Z
dc.date.available2019-09-02T11:42:22Z
dc.date.issued2014
dc.identifier.issn1073-9149
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2228
dc.description.abstractDrugs with antiepileptic activity constitute a group of heterogeneous compounds and therefore their determination cannot follow a universal procedure. Among them, vigabatrin, pregabalin, and gabapentin are of similar nature, due to their zwitterionic structure. This structure enables similar approaches for their determination, including derivatization protocols. This article presents a thorough survey on published methods for the determination of this subgroup of antiepileptic compounds in bulk and pharmaceutical preparations. Spectrophotometric and spectrofluorimetric methods, with or without derivatization reagents, as thin-layer chromatography, high-performance liquid chromatography with various detectors, gas chromatography, capillary electrophoresis, infrared, and potentiometric methods, have been extensively applied for these compounds, providing reliable results. Additionally, the number of citations and purpose for each method were discussed with critical commentary.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.rightsrestrictedAccess
dc.sourceInstrumentation Science & Technology
dc.subjectinstrumental methodsen
dc.subjectvigabatrinen
dc.subjectbulk drug and formulationsen
dc.subjectpregabalinen
dc.subjectgabapentinen
dc.titleCritical review on the analytical methods for the determination of zwitterionic antiepileptic drugs-Vigabatrin, Pregabalin, and Gabapentin - In bulk and formulationsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДотсикас, Yаннис; Маленовић, Aнђелија; Костић, Нада;
dc.citation.volume42
dc.citation.issue4
dc.citation.spage486
dc.citation.epage512
dc.citation.other42(4): 486-512
dc.citation.rankM23
dc.identifier.wos000335851000011
dc.identifier.doi10.1080/10739149.2013.876545
dc.identifier.scopus2-s2.0-84900443526
dc.identifier.rcubconv_3068
dc.type.versionpublishedVersion


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