Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia
Само за регистроване кориснике
2014
Аутори
Vidović, BojanaStefanović, Aleksandra
Milovanović, Srđan
Đorđević, Brižita
Kotur-Stevuljević, Jelena
Ivanišević, Jasmina
Miljković, Milica
Spasić, Slavica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background. The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination. Methods. Fasting glucose, lipid profi le and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects. Results. Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients. Conclusion. Increased oxidative stress and changed lipid profi le parameters are associated in schizophrenic patients an...d may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls.
Кључне речи:
Overweight / cardiovascular disease / antioxidative capacity / lipids / antipsychotic treatmentИзвор:
Scandinavian Journal of Clinical and Laboratory Investigation, 2014, 74, 3, 184-191Издавач:
- Informa Healthcare, London
Финансирање / пројекти:
DOI: 10.3109/00365513.2013.873947
ISSN: 0036-5513
PubMed: 24446766
WoS: 000334738200002
Scopus: 2-s2.0-84898459914
Институција/група
PharmacyTY - JOUR AU - Vidović, Bojana AU - Stefanović, Aleksandra AU - Milovanović, Srđan AU - Đorđević, Brižita AU - Kotur-Stevuljević, Jelena AU - Ivanišević, Jasmina AU - Miljković, Milica AU - Spasić, Slavica PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2230 AB - Background. The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination. Methods. Fasting glucose, lipid profi le and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects. Results. Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients. Conclusion. Increased oxidative stress and changed lipid profi le parameters are associated in schizophrenic patients and may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls. PB - Informa Healthcare, London T2 - Scandinavian Journal of Clinical and Laboratory Investigation T1 - Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia VL - 74 IS - 3 SP - 184 EP - 191 DO - 10.3109/00365513.2013.873947 ER -
@article{ author = "Vidović, Bojana and Stefanović, Aleksandra and Milovanović, Srđan and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Miljković, Milica and Spasić, Slavica", year = "2014", abstract = "Background. The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination. Methods. Fasting glucose, lipid profi le and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects. Results. Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients. Conclusion. Increased oxidative stress and changed lipid profi le parameters are associated in schizophrenic patients and may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls.", publisher = "Informa Healthcare, London", journal = "Scandinavian Journal of Clinical and Laboratory Investigation", title = "Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia", volume = "74", number = "3", pages = "184-191", doi = "10.3109/00365513.2013.873947" }
Vidović, B., Stefanović, A., Milovanović, S., Đorđević, B., Kotur-Stevuljević, J., Ivanišević, J., Miljković, M.,& Spasić, S.. (2014). Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia. in Scandinavian Journal of Clinical and Laboratory Investigation Informa Healthcare, London., 74(3), 184-191. https://doi.org/10.3109/00365513.2013.873947
Vidović B, Stefanović A, Milovanović S, Đorđević B, Kotur-Stevuljević J, Ivanišević J, Miljković M, Spasić S. Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(3):184-191. doi:10.3109/00365513.2013.873947 .
Vidović, Bojana, Stefanović, Aleksandra, Milovanović, Srđan, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Miljković, Milica, Spasić, Slavica, "Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 3 (2014):184-191, https://doi.org/10.3109/00365513.2013.873947 . .