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Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation

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2014
Authors
Tomić, Maja
Popović, Višnja
Petrović, Silvana
Stepanović-Petrović, Radica
Micov, Ana
Drobac, Milica
Couladis, Maria
Article (Published version)
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Abstract
From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 an...d 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright

Keywords:
Matricaria recutita essential oil / bisabolol oxides type / antihyperalgesic activity / antiedematous activity / localized inflammation
Source:
Phytotherapy Research, 2014, 28, 5, 759-766
Publisher:
  • Wiley-Blackwell, Hoboken
Funding / projects:
  • Examination of mechanisms of action, toxicity and interactions of adjuvant analgesics (RS-175045)

DOI: 10.1002/ptr.5057

ISSN: 0951-418X

PubMed: 23983133

WoS: 000334609800016

Scopus: 2-s2.0-84899473473
[ Google Scholar ]
25
20
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2234
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Tomić, Maja
AU  - Popović, Višnja
AU  - Petrović, Silvana
AU  - Stepanović-Petrović, Radica
AU  - Micov, Ana
AU  - Drobac, Milica
AU  - Couladis, Maria
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2234
AB  - From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 and 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation
VL  - 28
IS  - 5
SP  - 759
EP  - 766
DO  - 10.1002/ptr.5057
ER  - 
@article{
author = "Tomić, Maja and Popović, Višnja and Petrović, Silvana and Stepanović-Petrović, Radica and Micov, Ana and Drobac, Milica and Couladis, Maria",
year = "2014",
abstract = "From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 and 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation",
volume = "28",
number = "5",
pages = "759-766",
doi = "10.1002/ptr.5057"
}
Tomić, M., Popović, V., Petrović, S., Stepanović-Petrović, R., Micov, A., Drobac, M.,& Couladis, M.. (2014). Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 28(5), 759-766.
https://doi.org/10.1002/ptr.5057
Tomić M, Popović V, Petrović S, Stepanović-Petrović R, Micov A, Drobac M, Couladis M. Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation. in Phytotherapy Research. 2014;28(5):759-766.
doi:10.1002/ptr.5057 .
Tomić, Maja, Popović, Višnja, Petrović, Silvana, Stepanović-Petrović, Radica, Micov, Ana, Drobac, Milica, Couladis, Maria, "Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation" in Phytotherapy Research, 28, no. 5 (2014):759-766,
https://doi.org/10.1002/ptr.5057 . .

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