Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation
rcub.bitstream.locked
2014
Authors
Tomić, Maja
Popović, Višnja
Petrović, Silvana

Stepanović-Petrović, Radica

Micov, Ana

Drobac, Milica

Couladis, Maria
Article (Published version)

Metadata
Show full item recordAbstract
From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 an...d 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright
Keywords:
Matricaria recutita essential oil / bisabolol oxides type / antihyperalgesic activity / antiedematous activity / localized inflammationSource:
Phytotherapy Research, 2014, 28, 5, 759-766Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
DOI: 10.1002/ptr.5057
ISSN: 0951-418X
PubMed: 23983133
WoS: 000334609800016
Scopus: 2-s2.0-84899473473
Collections
Institution/Community
PharmacyTY - JOUR AU - Tomić, Maja AU - Popović, Višnja AU - Petrović, Silvana AU - Stepanović-Petrović, Radica AU - Micov, Ana AU - Drobac, Milica AU - Couladis, Maria PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2234 AB - From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 and 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright PB - Wiley-Blackwell, Hoboken T2 - Phytotherapy Research T1 - Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation VL - 28 IS - 5 SP - 759 EP - 766 DO - 10.1002/ptr.5057 ER -
@article{ author = "Tomić, Maja and Popović, Višnja and Petrović, Silvana and Stepanović-Petrović, Radica and Micov, Ana and Drobac, Milica and Couladis, Maria", year = "2014", abstract = "From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 and 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyright", publisher = "Wiley-Blackwell, Hoboken", journal = "Phytotherapy Research", title = "Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation", volume = "28", number = "5", pages = "759-766", doi = "10.1002/ptr.5057" }
Tomić, M., Popović, V., Petrović, S., Stepanović-Petrović, R., Micov, A., Drobac, M.,& Couladis, M.. (2014). Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation. in Phytotherapy Research Wiley-Blackwell, Hoboken., 28(5), 759-766. https://doi.org/10.1002/ptr.5057
Tomić M, Popović V, Petrović S, Stepanović-Petrović R, Micov A, Drobac M, Couladis M. Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation. in Phytotherapy Research. 2014;28(5):759-766. doi:10.1002/ptr.5057 .
Tomić, Maja, Popović, Višnja, Petrović, Silvana, Stepanović-Petrović, Radica, Micov, Ana, Drobac, Milica, Couladis, Maria, "Antihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammation" in Phytotherapy Research, 28, no. 5 (2014):759-766, https://doi.org/10.1002/ptr.5057 . .