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dc.creatorTomić, Maja
dc.creatorPopović, Višnja
dc.creatorPetrović, Silvana
dc.creatorStepanović-Petrović, Radica
dc.creatorMicov, Ana
dc.creatorDrobac, Milica
dc.creatorCouladis, Maria
dc.date.accessioned2019-09-02T11:42:30Z
dc.date.available2019-09-02T11:42:30Z
dc.date.issued2014
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2234
dc.description.abstractFrom the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in the obtained blue oil, -bisabolol oxide A (21.5%), -bisabolol oxide B (25.5%) and (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as the main compounds, by gas chromatography (GC) and GC-mass spectrometry analyses. The antihyperalgesic effects of this oil were examined in a rat model of inflammation induced by carrageenan, through a modified paw-pressure' test. Antiedematous effects were examined in a rat model of inflammation induced by carrageenan, dextran and histamine, through plethysmometry. Matricaria oil (25, 50 and 100mg/kg, p.o.) exhibited a significant dose-dependent reduction of hyperalgesia and edema induced by carrageenan in both prophylactic and therapeutic treatment schemes. It was more efficacious in the prophylactic treatment scheme, and the corresponding median effective dose (ED50)+/- standard error of the mean (SEM) values were 49.8 +/- 6.0 and 42.4 +/- 0.2mg/kg for antihyperalgesic and antiedematous effects, respectively. Prophylactic treatments with matricaria oil (25, 50 and 100mg/kg, p.o.) caused a significant dose-dependent antiedematous effect in dextran-induced edema with lower efficacy than in the carrageenan model. In a dose of 100mg/kg, p.o., matricaria oil caused a slight reduction of histamine-induced edema. These results suggest that bisabolol-oxide-rich matricaria oil may be effective against pain and edema present in various inflammatory conditions, which supports matricaria traditional uses. Copyrighten
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.subjectMatricaria recutita essential oilen
dc.subjectbisabolol oxides typeen
dc.subjectantihyperalgesic activityen
dc.subjectantiedematous activityen
dc.subjectlocalized inflammationen
dc.titleAntihyperalgesic and Antiedematous Activities of Bisabolol-Oxides-Rich Matricaria Oil in a Rat Model of Inflammationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМицов, Aна; Степановић-Петровић, Радица; Дробац, Милица; Томић, Маја; Цоуладис, Мариа; Поповић, Вишња; Петровић, Силвана;
dc.citation.volume28
dc.citation.issue5
dc.citation.spage759
dc.citation.epage766
dc.citation.other28(5): 759-766
dc.citation.rankM22
dc.identifier.wos000334609800016
dc.identifier.doi10.1002/ptr.5057
dc.identifier.pmid23983133
dc.identifier.scopus2-s2.0-84899473473
dc.identifier.rcubconv_3063
dc.type.versionpublishedVersion


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