Modified Natural Zeolites-Functional Characterization and Biomedical Application
Abstract
Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modi...fi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.
Keywords:
Adsorption / Cationic surfactant / Clinoptilolite / Drugs / Functionality related characteristics / Mycotoxins / Organozeolites/composites / Pharmaceutical excipientsSource:
Advanced Healthcare Materials, 2014, 359-403Publisher:
- Wiley Blackwell
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
- Oxide-based environmentally-friendly porous materials for genotoxic substances removal (RS-172018)
Collections
Institution/Community
PharmacyTY - CHAP AU - Milić, Jela AU - Daković, Aleksandra AU - Krajišnik, Danina AU - Rottinghaus, George E. PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2259 AB - Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients. PB - Wiley Blackwell T2 - Advanced Healthcare Materials T1 - Modified Natural Zeolites-Functional Characterization and Biomedical Application SP - 359 EP - 403 DO - 10.1002/9781118774205.ch10 ER -
@inbook{ author = "Milić, Jela and Daković, Aleksandra and Krajišnik, Danina and Rottinghaus, George E.", year = "2014", abstract = "Natural and synthetic zeolites have emerged as potential materials for biomedical application in recent years. Zeolites are hydrated microporous tektoaluminosilicates consisting of three-dimensional frameworks of SiO4 and AlO4 tetrahedra linked through shared oxygen atoms. Clinoptilolite, a mineral from the heulandite group of zeolites, ((Na,K)6(Al6Si3O)O72·nH2O), is the most abundant sedimentary zeolite in nature. In this chapter an overview of surface modifi cation of clinoptilolite by interaction with cationic surfactants is given alongside with the methods used for characterization of the surfactant modifi ed zeolites (organozeolites/composites). Diff erent organozeolites were tested under conditions for adsorption of several mycotoxins commonly found in animal feed. Study of in vitro surfactant desorption in vitro followed by in vivo acute toxicity testing was used to demonstrate the nontoxic nature of these improved mineral materials. Functionality related characteristics of modifi ed natural zeolites were analyzed for investigation of their potential use as pharmaceutical excipients for modifi ed release of active pharmaceutical ingredients.", publisher = "Wiley Blackwell", journal = "Advanced Healthcare Materials", booktitle = "Modified Natural Zeolites-Functional Characterization and Biomedical Application", pages = "359-403", doi = "10.1002/9781118774205.ch10" }
Milić, J., Daković, A., Krajišnik, D.,& Rottinghaus, G. E.. (2014). Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials Wiley Blackwell., 359-403. https://doi.org/10.1002/9781118774205.ch10
Milić J, Daković A, Krajišnik D, Rottinghaus GE. Modified Natural Zeolites-Functional Characterization and Biomedical Application. in Advanced Healthcare Materials. 2014;:359-403. doi:10.1002/9781118774205.ch10 .
Milić, Jela, Daković, Aleksandra, Krajišnik, Danina, Rottinghaus, George E., "Modified Natural Zeolites-Functional Characterization and Biomedical Application" in Advanced Healthcare Materials (2014):359-403, https://doi.org/10.1002/9781118774205.ch10 . .