Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.
TY - JOUR
AU - Dukić, M
AU - Jovanović, M
AU - Nedeljković, M
AU - Ignjatović, Svetlana
AU - Antonijević, Biljana
PY - 1999
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/226
AB - Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.
PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2 - Jugoslovenska medicinska biohemija
T1 - Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics
VL - 18
IS - 4
SP - 161
EP - 165
UR - https://hdl.handle.net/21.15107/rcub_farfar_226
ER -
@article{
author = "Dukić, M and Jovanović, M and Nedeljković, M and Ignjatović, Svetlana and Antonijević, Biljana",
year = "1999",
abstract = "Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics",
volume = "18",
number = "4",
pages = "161-165",
url = "https://hdl.handle.net/21.15107/rcub_farfar_226"
}
Dukić, M., Jovanović, M., Nedeljković, M., Ignjatović, S.,& Antonijević, B.. (1999). Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 18(4), 161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226
Dukić M, Jovanović M, Nedeljković M, Ignjatović S, Antonijević B. Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija. 1999;18(4):161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226 .
Dukić, M, Jovanović, M, Nedeljković, M, Ignjatović, Svetlana, Antonijević, Biljana, "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics" in Jugoslovenska medicinska biohemija, 18, no. 4 (1999):161-165,
https://hdl.handle.net/21.15107/rcub_farfar_226 .
