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Occupational and environmental aspects of organophosphorus compounds

Authorized Users Only
2014
Authors
Vučinić, Slavica
Antonijević, Biljana
Brkić, Dragica
Book part (Published version)
Metadata
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Abstract
Besides being a potential risk to humans and other living organisms, organophosphorus (OP) compounds also poses a risk to the environment. Production and placing pesticides on the market are under national and international legislative framework, although in many developing countries the regulation is still inadequate or not properly enforced. Occupational exposure to OPs includes any job which involves either direct or indirect contact with OP compounds, while public exposure to OPs may occur through contaminated food or from hand-to-mouth contact with contaminated surfaces, inhalation and dermal contact. The aim of this chapter is to present a comprehensive review of control and regulation measures, risk assessment methods, types and modality of occupational and environmental exposure to OPs, and ecotoxicology of these compounds. Review of the literature on OP exposure in electronic bibliographic databases, textbooks, and Internet sources was done. The acute high-dose effects of OPs ...are well known and include neurological dysfunction due to the inhibition of acetylcholinesterase (AChE), while effects of low-level exposure are still a matter of controversy. Advances in analytical methods help scientists to find new biomarkers of exposure and tools for biological monitoring and regulations of occupational exposure.

Keywords:
Butyrylcholinesterase / Chemical weapons convention / Dialkyl phosphate / Diethyldithiophosphate / Diethylphosphate / Diethylthiophosphate / Dimethyldithiophosphate / Dimethylphosphate / Dimethylthiophos
Source:
Basic and Clinical Toxicology of Organophosphorus Compounds, 2014, 213-244
Publisher:
  • Springer-Verlag London Ltd
Projects:
  • Development of integrated management of harmful organisms in plant production in order to overcome resistance and to improve food quality and safety (RS-46008)
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)
  • Geologic and ecotoxicologic research in identification of geopathogen zones of toxic elements in drinking water reservoirs- research into methods and procedures for reduction of biochemical anomalies (RS-176018)

DOI: 10.1007/978-1-4471-5625-3_8

Scopus: 2-s2.0-84956529315
[ Google Scholar ]
2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2263
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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