The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins.
TY - JOUR
AU - Kuntić, Vesna
AU - Filipović-Ljesković, L
AU - Malešev, Dušan
AU - Jelić, S
PY - 1999
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/227
AB - The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins.
PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2 - Jugoslovenska medicinska biohemija
T1 - Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"
VL - 18
IS - 4
SP - 167
EP - 169
UR - https://hdl.handle.net/21.15107/rcub_farfar_227
ER -
@article{
author = "Kuntić, Vesna and Filipović-Ljesković, L and Malešev, Dušan and Jelić, S",
year = "1999",
abstract = "The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"",
volume = "18",
number = "4",
pages = "167-169",
url = "https://hdl.handle.net/21.15107/rcub_farfar_227"
}
Kuntić, V., Filipović-Ljesković, L., Malešev, D.,& Jelić, S.. (1999). Effects of flavonoids on plasma coagulation tested in vitro by "screening tests". in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 18(4), 167-169.
https://hdl.handle.net/21.15107/rcub_farfar_227
Kuntić V, Filipović-Ljesković L, Malešev D, Jelić S. Effects of flavonoids on plasma coagulation tested in vitro by "screening tests". in Jugoslovenska medicinska biohemija. 1999;18(4):167-169.
https://hdl.handle.net/21.15107/rcub_farfar_227 .
Kuntić, Vesna, Filipović-Ljesković, L, Malešev, Dušan, Jelić, S, "Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"" in Jugoslovenska medicinska biohemija, 18, no. 4 (1999):167-169,
https://hdl.handle.net/21.15107/rcub_farfar_227 .
