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Mikroigle - fizički pojačivači (trans)dermalne isporuke lijekova

dc.creatorVučen, Sonja
dc.creatorBubić-Pajić, Nataša
dc.creatorSavić, Snežana
dc.creatorVuleta, Gordana
dc.date.accessioned2019-09-02T11:43:33Z
dc.date.available2019-09-02T11:43:33Z
dc.date.issued2014
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2273
dc.description.abstractThe efficiency of(trans)dermal drug delivery has been severely reduced by the inability of most drugs to penetrate the skin at therapeutically useful rates. Recently, the use of micron-scale needles has been shown to increase skin permeability and significantly improve (trans)dermal drug delivery, particularly for macromolecules. Using the tools of the microelectronics industry and different materials, microneedles of various sizes and shapes have been fabricated. Due to their micron size (less than 300 μm in diameter and 50-900 μm in length), these needles do not reach the nerve endings in the dermis, providing a painless application, which is considered as their main advantage over hypodermic needles. Pathways created using microneedles are orders of magnitude bigger than molecular dimensions and, therefore, should readily permit transport of macromolecules, as well as possibly supramolecular complexes and microparticles Recently, in vivo studies have demonstrated a successful delivery of oligonucleotides, insulin, and many other drugs using a microneedles, as well as induction of the immune response from protein and DNA vaccines. Numerous studies conducted in this research field have led to launching the first microneedle-based (trans)dermal drug delivery systems on the market.en
dc.description.abstractEfikasnost terapijskih sistema za (trans)dermalnu isporuku lijekova je u znatnoj mjeri umanjena zbog otežanog prolaska lijekova u/kroz kožu. Nedavno je pokazano da je upotrebom igala mikronskih veličina moguće povećati permeabilnost kože i znatno poboljšati (trans)dermalnu isporuku, naročito u slučaju makromolekula. Primjenom dostignuća mikroelektronske industrije, od različitih materijala su proizvedene mikroigle različitih veličina i oblika. S obzirom na svoje mikronske veličine (prečnika obično oko 1 μm i dužine 50-900 μm), ovakve igle ne dopiru do nervnih završetaka u dermisu, čime obezbjeđuju bezbolnu primjenu, što se smatra njihovom osnovnom prednošću u odnosu na potkožne igle. Nastale pore u koži su nekoliko puta veće od dimenzija molekula, te je omogućen transport makromolekula, kao i supramolekularnih kompleksa i nano/mikročestica. Dosadašnje in vivo studije su pokazale uspješnu (trans)dermalnu isporuku oligonukleotida, insulina i drugih lijekova primjenom mikroigala, kao i indukciju imunskog odgovora proteinskim i DNK vakcinama. Brojni radovi sprovedeni u ovoj oblasti istraživanja doveli su i do pojave na tržištu prvih sistema za (trans)dermalnu isporuku lijekova zasnovanih na tehnologiji mikroigala.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subject(trans)dermal drug deliveryen
dc.subjectmicroneedlesen
dc.subjectphysical percutaneous penetration enhancersen
dc.subjectmaterials for microneedle fabricationen
dc.subject(trans)dermalna isporuka lijekasr
dc.subjectmikroiglesr
dc.subjectfizički pojačivači perkutane penetracijesr
dc.subjectmaterijali za mikroiglesr
dc.titleMicroneedles: Physical enhancers for (trans)dermal drug deliveryen
dc.titleMikroigle - fizički pojačivači (trans)dermalne isporuke lijekovasr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractСавић, Снежана; Вулета, Гордана; Бубић-Пајић, Наташа; Вучен, Соња; Микроигле - физички појачивачи (транс)дермалне испоруке лијекова; Микроигле - физички појачивачи (транс)дермалне испоруке лијекова;
dc.citation.volume64
dc.citation.issue4
dc.citation.spage295
dc.citation.epage321
dc.citation.other64(4): 295-321
dc.citation.rankM53
dc.identifier.doi10.5937/arhfarm1404295V
dc.identifier.scopus2-s2.0-84943638007
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/986/2271.pdf
dc.identifier.rcubconv_525
dc.type.versionpublishedVersion


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