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Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat

Plaket-Burman dizajn u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata

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2014
2277.pdf (489.9Kb)
Authors
Kojić-Marinković, Slavica
Tumbas, Mihaela
Rakić, Tijana
Jančić-Stojanović, Biljana
Article (Published version)
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Abstract
In this paper, application of Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium valproate. As factors which could have influence on method's robustness content of acetonitrile, concentration of sodium dihydrogenphosphate, pH of the mobile phase, column's temperature, flow rate and wavelenght were investigated. In aim to create plan of experiments for Plackett-Burman design on six real factors, 5 dummies were added. In total, 11 factors were investigated throught 12 experiments. As qualitative responses retention times, number of theoretical plates and peak symmetry were followed while as quantitative response peak area was followed. On the basis of the obtained results with statistical and graphical methods, influence of investigated factors on system responses were defined. Further, for significant factors non-significant interval was defined e. g. range in which factor could be change without influence on response. Finally, resu...lts were used for determination of parameters for system suitability tests.

U ovom radu opisana je primena Plaket-Burman dizajna u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata. Kao faktori koji mogu uticati na robusnost metode ispitani su sadržaj acetonitrila, koncentracija natrijum-dihidrogenfosfata, pH vrednost mobilne faze, temperatura kolone, protok mobilne faze i talasna dužina detekcije. U cilju kreiranja plana eksperimenta prema Plaket-Burman dizajnu, na 6 pravih faktora dodato je 5 veštačkih faktora i tako je ispitano 11 faktora izvođenjem 12 eksperimenata. Kao odgovori sistema praćeni su retenciono vreme, broj teorijskih platoa i simetrija pika kao kvalitativni odgovori, dok je kao kvantitativni odgovor praćena površina pika. Na osnovu dobijenih rezultata, a primenom odgovarajućih statističkih i grafičkih metoda, procenjen je uticaj ispitivanih faktora na posmatrane odgovore sistema. Pored toga, za značajne faktore određen je interval pouzdanosti tj. opseg u okviru koga se mogu menjati, a da to ne utiče zna...čajno na odgovor sistema. Na kraju, na osnovu dobijenih rezultata, određeni su i parametri za proveru pogodnosti sistema.

Keywords:
Plackett-Burman design / robustness / sodium valproate / liquid chromatography / Plaket-Burman dizajn / robusnost / natrijum-valproat / tečna hromatografija
Source:
Arhiv za farmaciju, 2014, 64, 2, 128-143
Publisher:
  • Savez farmaceutskih udruženja Srbije, Beograd
Funding / projects:
  • Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)

DOI: 10.5937/arhfarm1402128K

ISSN: 0004-1963

Scopus: 2-s2.0-84943599013
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2279
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Kojić-Marinković, Slavica
AU  - Tumbas, Mihaela
AU  - Rakić, Tijana
AU  - Jančić-Stojanović, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2279
AB  - In this paper, application of Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium valproate. As factors which could have influence on method's robustness content of acetonitrile, concentration of sodium dihydrogenphosphate, pH of the mobile phase, column's temperature, flow rate and wavelenght were investigated. In aim to create plan of experiments for Plackett-Burman design on six real factors, 5 dummies were added. In total, 11 factors were investigated throught 12 experiments. As qualitative responses retention times, number of theoretical plates and peak symmetry were followed while as quantitative response peak area was followed. On the basis of the obtained results with statistical and graphical methods, influence of investigated factors on system responses were defined. Further, for significant factors non-significant interval was defined e. g. range in which factor could be change without influence on response. Finally, results were used for determination of parameters for system suitability tests.
AB  - U ovom radu opisana je primena Plaket-Burman dizajna u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata. Kao faktori koji mogu uticati na robusnost metode ispitani su sadržaj acetonitrila, koncentracija natrijum-dihidrogenfosfata, pH vrednost mobilne faze, temperatura kolone, protok mobilne faze i talasna dužina detekcije. U cilju kreiranja plana eksperimenta prema Plaket-Burman dizajnu, na 6 pravih faktora dodato je 5 veštačkih faktora i tako je ispitano 11 faktora izvođenjem 12 eksperimenata. Kao odgovori sistema praćeni su retenciono vreme, broj teorijskih platoa i simetrija pika kao kvalitativni odgovori, dok je kao kvantitativni odgovor praćena površina pika. Na osnovu dobijenih rezultata, a primenom odgovarajućih statističkih i grafičkih metoda, procenjen je uticaj ispitivanih faktora na posmatrane odgovore sistema. Pored toga, za značajne faktore određen je interval pouzdanosti tj. opseg u okviru koga se mogu menjati, a da to ne utiče značajno na odgovor sistema. Na kraju, na osnovu dobijenih rezultata, određeni su i parametri za proveru pogodnosti sistema.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat
T1  - Plaket-Burman dizajn u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata
VL  - 64
IS  - 2
SP  - 128
EP  - 143
DO  - 10.5937/arhfarm1402128K
ER  - 
@article{
author = "Kojić-Marinković, Slavica and Tumbas, Mihaela and Rakić, Tijana and Jančić-Stojanović, Biljana",
year = "2014",
abstract = "In this paper, application of Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium valproate. As factors which could have influence on method's robustness content of acetonitrile, concentration of sodium dihydrogenphosphate, pH of the mobile phase, column's temperature, flow rate and wavelenght were investigated. In aim to create plan of experiments for Plackett-Burman design on six real factors, 5 dummies were added. In total, 11 factors were investigated throught 12 experiments. As qualitative responses retention times, number of theoretical plates and peak symmetry were followed while as quantitative response peak area was followed. On the basis of the obtained results with statistical and graphical methods, influence of investigated factors on system responses were defined. Further, for significant factors non-significant interval was defined e. g. range in which factor could be change without influence on response. Finally, results were used for determination of parameters for system suitability tests., U ovom radu opisana je primena Plaket-Burman dizajna u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata. Kao faktori koji mogu uticati na robusnost metode ispitani su sadržaj acetonitrila, koncentracija natrijum-dihidrogenfosfata, pH vrednost mobilne faze, temperatura kolone, protok mobilne faze i talasna dužina detekcije. U cilju kreiranja plana eksperimenta prema Plaket-Burman dizajnu, na 6 pravih faktora dodato je 5 veštačkih faktora i tako je ispitano 11 faktora izvođenjem 12 eksperimenata. Kao odgovori sistema praćeni su retenciono vreme, broj teorijskih platoa i simetrija pika kao kvalitativni odgovori, dok je kao kvantitativni odgovor praćena površina pika. Na osnovu dobijenih rezultata, a primenom odgovarajućih statističkih i grafičkih metoda, procenjen je uticaj ispitivanih faktora na posmatrane odgovore sistema. Pored toga, za značajne faktore određen je interval pouzdanosti tj. opseg u okviru koga se mogu menjati, a da to ne utiče značajno na odgovor sistema. Na kraju, na osnovu dobijenih rezultata, određeni su i parametri za proveru pogodnosti sistema.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat, Plaket-Burman dizajn u proceni robusnosti metode tečne hromatografije za određivanje sadržaja natrijum-valproata",
volume = "64",
number = "2",
pages = "128-143",
doi = "10.5937/arhfarm1402128K"
}
Kojić-Marinković, S., Tumbas, M., Rakić, T.,& Jančić-Stojanović, B.. (2014). Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(2), 128-143.
https://doi.org/10.5937/arhfarm1402128K
Kojić-Marinković S, Tumbas M, Rakić T, Jančić-Stojanović B. Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat. in Arhiv za farmaciju. 2014;64(2):128-143.
doi:10.5937/arhfarm1402128K .
Kojić-Marinković, Slavica, Tumbas, Mihaela, Rakić, Tijana, Jančić-Stojanović, Biljana, "Plackett-Burman design in robustness testing of liquid chromatographic method for determination of sodium-valproat" in Arhiv za farmaciju, 64, no. 2 (2014):128-143,
https://doi.org/10.5937/arhfarm1402128K . .

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