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Vaskularni stentovi - najznačajnije vrste i osobine

dc.creatorDrakul, Dragana
dc.creatorMatić, Predrag
dc.creatorDrobac, Milica
dc.creatorKostić, Nađa
dc.creatorVemić, Ana
dc.creatorVasiljević, Dragana
dc.creatorMalenović, Anđelija
dc.date.accessioned2019-09-02T11:43:58Z
dc.date.available2019-09-02T11:43:58Z
dc.date.issued2014
dc.identifier.issn0004-1963
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2291
dc.description.abstractVascular stents are general medical devices of class III or IIb, which are placed along the walls of the constricted coronary and peripheral blood vessels thus keeping them viable. According to the mechanism of expansion, stents may be balloon-expandable or self-expanding. Depending on the geometry they can be classified into: coil stents, open-cell modular stents and multi-cell closed cell stents. The most important characteristic of vascular stents is their flexibility, but a number of additional requirements must also be met: high radial strength, low elastic deformation, small diameter, the possibility of monitoring through the bloodstream, minimum subsequent shortening, minimum elastic longitudinal deformation, and the optimal retention at target site. Materials for production of stents must be biologically inert, visible by radiological techniques, biocompatible, corrosion-resistant and resistant to stress due to blood flow. The most significant adverse event after stent implantation is the occurrence of restenosis, which is most efficiently overcome by the application of drug releasing stents. These stents are composed of three parts: stent platform, drug carrier and a drug that inhibits neointimal hyperplasia - paclitaxel and limuses (sirolimus, everolimus, zotarolimus, tacrolimus, pimecrolimus, etc.). In recent years, stents with surfaces coated with substances that accelerate endothelialisation and thus reduce thrombosis have been developed. The latest approach is represented by a stent with the lumen coated with CD34 antibody, and the outer side coated with sirolimus. By using these devices a double effect is achieved: acceleration of endothelialisation and inhibition of neointimal hyperplasia.en
dc.description.abstractVaskularni stentovi su opšta medicinska sredstva klase III ili IIb, koja se postavljaju uz zidove koronarnih i perifernih krvnih sudova kada postoji suženje i na taj način ih održavaju prohodnim. Prema mehanizmu ekspanzije, stentovi mogu biti balon-ekspandirajući ili samoekspandirajući, a u zavisnosti od geometrijskog oblika dele se na: stentove u obliku spirale, modularne stentove sa otvorenim ćelijama i multićelijske stentove sa zatvorenim ćelijama. Najznačajnija karakteristika vaskularnih stentova je fleksibilnost, ali moraju da ispunjavaju i čitav niz dodatnih zahteva, kao što su: velika radijalna snaga, nizak stepen elastične deformacije, mali prečnik, mogućnost praćenja kroz krvotok, minimalno naknadno skraćivanje, minimalna elastična longitudinalna deformacija i optimalno zadržavanje na ciljnom mestu. Materijali za proizvodnju stentova moraju biti biološki inertni, vidljivi radiološkim tehnikama, biokompatibilni, otporni na koroziju i otporni na stres zbog protoka krvi. Najznačajniji neželjeni događaj nakon ugradnje stentova je pojava restenoze, koja se najefikasnije prevazilazi primenom stentova koji oslobađaju lek. Ovi stentovi se sastoje iz tri dela: platforme stenta, nosača leka i leka koji inhibira neointimalnu hiperplaziju, paklitaksel i limusi (sirolimus, everolimus, zotarolimus, takrolimus, pimekrolimus i dr). Poslednjih godina razvijeni su i stentovi kod kojih se površine oblažu supstancama koje ubrzavaju endotelizaciju i tako smanjuju trombozu. Najnoviji pristup predstavlja stent kod koga se lumen stenta oblaže CD34 antitelom, a spoljašnja strana sirolimusom. Primenom ovih stentova postiže se dvostruki efekat: ubrzavanje endotelizacije i inhibicija neointimalne hiperplazije.sr
dc.publisherSavez farmaceutskih udruženja Srbije, Beograd
dc.rightsopenAccess
dc.sourceArhiv za farmaciju
dc.subjectvascular stentsen
dc.subjectballoon-expandable stentsen
dc.subjectself-expanding stentsen
dc.subjectproduction materialsen
dc.subjectrestenosisen
dc.subjectvaskularni stentovisr
dc.subjectbalon-ekspandirajući stentovisr
dc.subjectsamoekspandirajući stentovisr
dc.subjectmaterijali za izradusr
dc.subjectrestenozasr
dc.titleVascular stents: The most important types and characteristicsen
dc.titleVaskularni stentovi - najznačajnije vrste i osobinesr
dc.typearticle
dc.rights.licenseBY-SA
dcterms.abstractВемић, Aна; Матић, Предраг; Васиљевић, Драгана; Дракул, Драгана; Дробац, Милица; Маленовић, Aнђелија; Костић, Нађа; Васкуларни стентови - најзначајније врсте и особине; Васкуларни стентови - најзначајније врсте и особине;
dc.citation.volume64
dc.citation.issue5
dc.citation.spage421
dc.citation.epage437
dc.citation.other64(5): 421-437
dc.citation.rankM53
dc.identifier.doi10.5937/arhfarm1405421D
dc.identifier.scopus2-s2.0-84943592300
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1004/2289.pdf
dc.identifier.rcubconv_529
dc.type.versionpublishedVersion


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