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dc.creatorStanojević, Stanislava
dc.creatorKovačević-Jovanović, Vesna
dc.creatorDimitrijević, Mirjana
dc.creatorVujić, Vesna
dc.creatorCuruvija, Ivana
dc.creatorBlagojević, Veljko
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:44:12Z
dc.date.available2019-09-02T11:44:12Z
dc.date.issued2015
dc.identifier.issn1046-7408
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2298
dc.description.abstractProblem The influence of unopposed estrogen replacement/isolated progesterone deficiency on macrophage production of pro-inflammatory/anti-inflammatory mediators in the post-reproductive age was studied. Method of study Considering that in the rats post-ovariectomy the circulating estradiol, but not progesterone level rises to the values in sham-operated controls, 20-month-old rats ovariectomized at the age of 10 months served as an experimental model. Estrogen and progesterone receptor expression, secretion of pro- and anti-inflammatory cytokines, and arginine metabolism end-products were examined in splenic and peritoneal macrophages under basal conditions and following lipopolysaccharide (LPS) stimulation in vitro. Results Almost all peritoneal and a subset of splenic macrophages expressed the intracellular progesterone receptor. Ovariectomy diminished cytokine production by splenic (IL-1 beta) and peritoneal (TNF-alpha, IL-1 beta, IL-10) macrophages and increased the production of IL-10 by splenic and TGF-beta by peritoneal cells under basal conditions. Following LPS stimulation, splenic macrophages from ovariectomized rats produced less TNF-alpha and more IL-10, whereas peritoneal macrophages produced less IL-1 beta and TGF-beta than the corresponding cells from sham-operated rats. Ovariectomy diminished urea production in both subpopulations of LPS-stimulated macrophages. Conclusion Although long-lasting isolated progesterone deficiency in the post-reproductive age differentially affects cytokine production in the macrophages from distinct tissue compartments, in both subpopulations, it impairs the pro- inflammatory/anti-inflammatory cytokine secretory balance.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceAmerican Journal of Reproductive Immunology
dc.titleUnopposed Estrogen Supplementation/Progesterone Deficiency in Post-Reproductive Age Affects the Secretory Profile of Resident Macrophages in a Tissue-Specific Manner in the Raten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛепосавић, Гордана; Благојевић, Вељко; Димитријевић, Мирјана; Вујић, Весна; Станојевић, Станислава; Ковачевић-Јовановић, Весна; Цурувија, Ивана;
dc.citation.volume74
dc.citation.issue5
dc.citation.spage445
dc.citation.epage456
dc.citation.other74(5): 445-456
dc.citation.rankM22
dc.identifier.wos000364913300007
dc.identifier.doi10.1111/aji.12424
dc.identifier.pmid26307150
dc.identifier.scopus2-s2.0-84944152233
dc.type.versionpublishedVersion


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