Determination of maprotiline hydrochloride by capillary zone electrophoresis

Abstract

A simple capillary zone electrophoresis method using a fused silica capillary was developed for the quantitation of maprotiline hydrochloride in Maprotilin tablets and Ludiomil ampoules. The sample was pressure-injected into the capillary (3 psis-1) in a run buffer of methanol-phosphate buffer. The optimum running voltage was 20kV and UV detection was at 200 nm. Linearity, precision and reproducibility of the method were good. The developed method is simple and rapid (approx. 10 min) and can be used for the routine analysis of maprotiline.