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Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice

Authorized Users Only
2015
Authors
Živković, Irena
Bufan, Biljana
Petrusić, Vladimir
Minić, Rajna
Arsenović-Ranin, Nevena
Petrović, Raisa
Leposavić, Gordana
Article (Published version)
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Abstract
An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points pos...t-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV.

Source:
Value in Health, 2015, 33, 42, 5546-5552
Publisher:
  • Elsevier Sci Ltd, Oxford
Projects:
  • Immune system plasticity during aging: Immunomodulatory capacity of oestrogens (RS-175050)

DOI: 10.1016/j.vaccine.2015.09.006

ISSN: 0264-410X

PubMed: 26382601

WoS: 000364268500013

Scopus: 2-s2.0-84943451379
[ Google Scholar ]
18
15
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2301
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Živković, Irena
AU  - Bufan, Biljana
AU  - Petrusić, Vladimir
AU  - Minić, Rajna
AU  - Arsenović-Ranin, Nevena
AU  - Petrović, Raisa
AU  - Leposavić, Gordana
PY  - 2015
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2301
AB  - An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points post-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV.
PB  - Elsevier Sci Ltd, Oxford
T2  - Value in Health
T1  - Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice
VL  - 33
IS  - 42
SP  - 5546
EP  - 5552
DO  - 10.1016/j.vaccine.2015.09.006
ER  - 
@article{
author = "Živković, Irena and Bufan, Biljana and Petrusić, Vladimir and Minić, Rajna and Arsenović-Ranin, Nevena and Petrović, Raisa and Leposavić, Gordana",
year = "2015",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2301",
abstract = "An outbred mouse model was used to determine if antibody response to immunization with whole-virus trivalent inactivated influenza vaccine (TIV) differs between the sexes. The antibody response was examined one (serum titer of IgM antibodies), and three and six weeks post-immunization (serum titer of neutralizing and total IgG antibodies and IgG subclass profile). Compared with male in female mice was found (i) the more robust IgM response against all influenza strains included in TIV and (ii) more vigorous neutralizing antibody and total IgG responses against H1N1 influenza virus at both the examined time points post-immunization. The total IgG antibody response against H3N2 and B influenza viruses was comparable between female and male mice three weeks post-immunization, but significantly greater in female mice six weeks post-immunization. The neutralizing antibody response against H3N2 and B influenza viruses did not significantly differ between sexes at both the examined points post-immunization. Finally, three weeks post-immunization subclass profile of IgG specific to the influenza strains included in TIV differed between female and male mice, reflecting the lower titer of IgG1 antibodies in female ones, so that IgG2a (contributing mainly to the total IgG) to IgG1 ratio in mice of this sex was shifted toward the former. In agreement with this shift, compared with male mice, Th1/Th2 balance in female mice was shifted toward Th1, as shown by ELISPOT. Collectively, the results showed influenza virus strain-dependent sexual dimorphism in the magnitude, dynamics and characteristics of antibody response in outbred mice immunized with TIV.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Value in Health",
title = "Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice",
volume = "33",
number = "42",
pages = "5546-5552",
doi = "10.1016/j.vaccine.2015.09.006"
}
Živković I, Bufan B, Petrusić V, Minić R, Arsenović-Ranin N, Petrović R, Leposavić G. Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice. Value in Health. 2015;33(42):5546-5552
Živković, I., Bufan, B., Petrusić, V., Minić, R., Arsenović-Ranin, N., Petrović, R.,& Leposavić, G. (2015). Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice.
Value in HealthElsevier Sci Ltd, Oxford., 33(42), 5546-5552.
https://doi.org/10.1016/j.vaccine.2015.09.006
Živković Irena, Bufan Biljana, Petrusić Vladimir, Minić Rajna, Arsenović-Ranin Nevena, Petrović Raisa, Leposavić Gordana, "Sexual diergism in antibody response to whole virus trivalent inactivated influenza vaccine in outbred mice" 33, no. 42 (2015):5546-5552,
https://doi.org/10.1016/j.vaccine.2015.09.006 .

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