FarFaR - Farmaceutski fakultet, repozitorijum
Univerzitet u Beogradu, Farmaceutski fakultet
    • English
    • Српски
    • Српски (Serbia)
  • Srpski (latinica) 
    • Engleski
    • Srpski (ćirilica)
    • Srpski (latinica)
  • Prijava
Pregled rada 
  •   FarFaR - Farmaceutski fakultet, repozitorijum
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Pregled rada
  •   FarFaR - Farmaceutski fakultet, repozitorijum
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • Pregled rada
JavaScript is disabled for your browser. Some features of this site may not work without it.

Alterations of the X Chromosome in Lymphocytes of Alzheimer's Disease Patients

Nema prikaza
Autori
Potparević, Biljana
Bajić, Vladan
Perry, George
Živković, Lada
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
Chromosomal alterations as a sign of genetic instability are a feature of Alzheimer's disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p lt 0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p lt 0.001). In addition, a strong (R2=0.97, n=20) and significant (p lt 0.001) correlation was found between the frequ...ency of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy.

Ključne reči:
Alzheimer's disease / aneuploidy / FISH / peripheral blood lymphocytes / PCD / X chromosome
Izvor:
Current Alzheimer Research, 2015, 12, 10, 990-996
Izdavač:
  • Bentham Science Publ Ltd, Sharjah
Projekti:
  • Aberacije ćelijskog ciklusa i uticaj oksidativnog stresa na neurodegenerativne procese i malignu transformaciju ćelije (RS-173034)

DOI: 10.2174/1567205012666151027124154

ISSN: 1567-2050

PubMed: 26502819

WoS: 000366135300009

Scopus: 2-s2.0-84959457872
[ Google Scholar ]
3
4
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2308
Kolekcije
  • Radovi istraživača / Researchers’ publications
Institucija
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
O FarFaR-u | Pošaljite zapažanja

OpenAIRERCUB
 

 

Kompletan repozitorijumInstitucijeAutoriNasloviTemeOva institucijaAutoriNasloviTeme

Statistika

Pregled statistika

DSpace software copyright © 2002-2015  DuraSpace
O FarFaR-u | Pošaljite zapažanja

OpenAIRERCUB