Show simple item record

dc.creatorPotparević, Biljana
dc.creatorBajić, Vladan
dc.creatorPerry, George
dc.creatorŽivković, Lada
dc.date.accessioned2019-09-02T11:44:26Z
dc.date.available2019-09-02T11:44:26Z
dc.date.issued2015
dc.identifier.issn1567-2050
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2308
dc.description.abstractChromosomal alterations as a sign of genetic instability are a feature of Alzheimer's disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p lt 0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p lt 0.001). In addition, a strong (R2=0.97, n=20) and significant (p lt 0.001) correlation was found between the frequency of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Alzheimer Research
dc.subjectAlzheimer's diseaseen
dc.subjectaneuploidyen
dc.subjectFISHen
dc.subjectperipheral blood lymphocytesen
dc.subjectPCDen
dc.subjectX chromosomeen
dc.titleAlterations of the X Chromosome in Lymphocytes of Alzheimer's Disease Patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПотпаревић, Биљана; Перрy, Георге; Живковић, Лада; Бајић, Владан;
dc.citation.volume12
dc.citation.issue10
dc.citation.spage990
dc.citation.epage996
dc.citation.other12(10): 990-996
dc.citation.rankM22
dc.identifier.wos000366135300009
dc.identifier.doi10.2174/1567205012666151027124154
dc.identifier.pmid26502819
dc.identifier.scopus2-s2.0-84959457872
dc.identifier.rcubconv_3440
dc.type.versionpublishedVersion


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record