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Alterations of the X Chromosome in Lymphocytes of Alzheimer's Disease Patients
dc.creator | Potparević, Biljana | |
dc.creator | Bajić, Vladan | |
dc.creator | Perry, George | |
dc.creator | Živković, Lada | |
dc.date.accessioned | 2019-09-02T11:44:26Z | |
dc.date.available | 2019-09-02T11:44:26Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1567-2050 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2308 | |
dc.description.abstract | Chromosomal alterations as a sign of genetic instability are a feature of Alzheimer's disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p lt 0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p lt 0.001). In addition, a strong (R2=0.97, n=20) and significant (p lt 0.001) correlation was found between the frequency of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS// | |
dc.rights | restrictedAccess | |
dc.source | Current Alzheimer Research | |
dc.subject | Alzheimer's disease | en |
dc.subject | aneuploidy | en |
dc.subject | FISH | en |
dc.subject | peripheral blood lymphocytes | en |
dc.subject | PCD | en |
dc.subject | X chromosome | en |
dc.title | Alterations of the X Chromosome in Lymphocytes of Alzheimer's Disease Patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Потпаревић, Биљана; Перрy, Георге; Живковић, Лада; Бајић, Владан; | |
dc.citation.volume | 12 | |
dc.citation.issue | 10 | |
dc.citation.spage | 990 | |
dc.citation.epage | 996 | |
dc.citation.other | 12(10): 990-996 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000366135300009 | |
dc.identifier.doi | 10.2174/1567205012666151027124154 | |
dc.identifier.pmid | 26502819 | |
dc.identifier.scopus | 2-s2.0-84959457872 | |
dc.type.version | publishedVersion |
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