FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity

No Thumbnail
Authors
Miljković, Milica
Đuričić, Ivana
Kotur-Stevuljević, Jelena
Šobajić, Slađana
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Kerkez, Mirko
Đorđević, Vladimir
Đurasić, Ljubomir
Spasić, Slavica
Article (Published version)
Metadata
Show full item record
Abstract
Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p lt 0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p lt 0.001). The present study show...ed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.

Keywords:
omega-3 fatty acids / oxidative stress / paraoxonase activity / high-density lipoprotein
Source:
Journal of Food and Nutrition Research, 2015, 54, 4, 314-322
Publisher:
  • Vup Food Research Inst, Bratislava
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

ISSN: 1336-8672

WoS: 000366342400005

[ Google Scholar ]
1
Handle
https://hdl.handle.net/21.15107/rcub_farfar_2312
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Miljković, Milica
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Šobajić, Slađana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Spasić, Slavica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312
AB  - Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.
PB  - Vup Food Research Inst, Bratislava
T2  - Journal of Food and Nutrition Research
T1  - Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity
VL  - 54
IS  - 4
SP  - 314
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2312
ER  - 
@article{
author = "Miljković, Milica and Đuričić, Ivana and Kotur-Stevuljević, Jelena and Šobajić, Slađana and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Spasić, Slavica",
year = "2015",
abstract = "Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.",
publisher = "Vup Food Research Inst, Bratislava",
journal = "Journal of Food and Nutrition Research",
title = "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity",
volume = "54",
number = "4",
pages = "314-322",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2312"
}
Miljković, M., Đuričić, I., Kotur-Stevuljević, J., Šobajić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kerkez, M., Đorđević, V., Đurasić, L.,& Spasić, S.. (2015). Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research
Vup Food Research Inst, Bratislava., 54(4), 314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312
Miljković M, Đuričić I, Kotur-Stevuljević J, Šobajić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kerkez M, Đorđević V, Đurasić L, Spasić S. Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research. 2015;54(4):314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312 .
Miljković, Milica, Đuričić, Ivana, Kotur-Stevuljević, Jelena, Šobajić, Slađana, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Spasić, Slavica, "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity" in Journal of Food and Nutrition Research, 54, no. 4 (2015):314-322,
https://hdl.handle.net/21.15107/rcub_farfar_2312 .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB