Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity
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Miljković, Milica
Đuričić, Ivana

Kotur-Stevuljević, Jelena

Šobajić, Slađana

Spasojević-Kalimanovska, Vesna

Jelić-Ivanović, Zorana

Kerkez, Mirko
Đorđević, Vladimir
Đurasić, Ljubomir
Spasić, Slavica
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Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p lt 0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p lt 0.001). The present study show...ed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.
Keywords:
omega-3 fatty acids / oxidative stress / paraoxonase activity / high-density lipoproteinSource:
Journal of Food and Nutrition Research, 2015, 54, 4, 314-322Publisher:
- Vup Food Research Inst, Bratislava
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PharmacyTY - JOUR AU - Miljković, Milica AU - Đuričić, Ivana AU - Kotur-Stevuljević, Jelena AU - Šobajić, Slađana AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana AU - Kerkez, Mirko AU - Đorđević, Vladimir AU - Đurasić, Ljubomir AU - Spasić, Slavica PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312 AB - Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p lt 0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p lt 0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation. PB - Vup Food Research Inst, Bratislava T2 - Journal of Food and Nutrition Research T1 - Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity VL - 54 IS - 4 SP - 314 EP - 322 UR - https://hdl.handle.net/21.15107/rcub_farfar_2312 ER -
@article{ author = "Miljković, Milica and Đuričić, Ivana and Kotur-Stevuljević, Jelena and Šobajić, Slađana and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Spasić, Slavica", year = "2015", abstract = "Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p lt 0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p lt 0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.", publisher = "Vup Food Research Inst, Bratislava", journal = "Journal of Food and Nutrition Research", title = "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity", volume = "54", number = "4", pages = "314-322", url = "https://hdl.handle.net/21.15107/rcub_farfar_2312" }
Miljković, M., Đuričić, I., Kotur-Stevuljević, J., Šobajić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kerkez, M., Đorđević, V., Đurasić, L.,& Spasić, S.. (2015). Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research Vup Food Research Inst, Bratislava., 54(4), 314-322. https://hdl.handle.net/21.15107/rcub_farfar_2312
Miljković M, Đuričić I, Kotur-Stevuljević J, Šobajić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kerkez M, Đorđević V, Đurasić L, Spasić S. Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research. 2015;54(4):314-322. https://hdl.handle.net/21.15107/rcub_farfar_2312 .
Miljković, Milica, Đuričić, Ivana, Kotur-Stevuljević, Jelena, Šobajić, Slađana, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Spasić, Slavica, "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity" in Journal of Food and Nutrition Research, 54, no. 4 (2015):314-322, https://hdl.handle.net/21.15107/rcub_farfar_2312 .