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dc.creatorBojić, Suzana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorKalezić, Nevena
dc.creatorStevanović, Predrag
dc.creatorJelić-Ivanović, Zorana
dc.creatorBilanović, Dragoljub
dc.creatorMemon, Lidija
dc.creatorDamnjanović, Mladen
dc.creatorKalaba, Zdravko
dc.creatorSimić-Ogrizović, Sanja
dc.date.accessioned2019-09-02T11:44:34Z
dc.date.available2019-09-02T11:44:34Z
dc.date.issued2015
dc.identifier.issn0040-8727
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2313
dc.description.abstractSepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix rnetalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n = 16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.en
dc.publisherTohoku Univ Medical Press, Sendai
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceToxicological and Environmental Chemistry
dc.titleDiagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injuryen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСимић-Огризовић, Сања; Дамњановић, Младен; Бојић, Сузана; Котур-Стевуљевић, Јелена; Билановић, Драгољуб; Калезић, Невена; Калаба, Здравко; Мемон, Лидија; Јелић-Ивановић, Зорана; Стевановић, Предраг;
dc.citation.volume237
dc.citation.issue2
dc.citation.spage103
dc.citation.epage109
dc.citation.other237(2): 103-109
dc.citation.rankM22
dc.identifier.wos000364501100004
dc.identifier.doi10.1620/tjem.237.103
dc.identifier.pmid26399271
dc.identifier.scopus2-s2.0-84942155717
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1025/2311.pdf
dc.type.versionpublishedVersion


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