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dc.creatorTimić-Stamenić, Tamara
dc.creatorJoksimović, Srđan
dc.creatorBiawat, Poonam
dc.creatorStanković, Tamara
dc.creatorMarković, Bojan
dc.creatorCook, James M.
dc.creatorSavić, Miroslav
dc.date.accessioned2019-09-02T11:44:36Z
dc.date.available2019-09-02T11:44:36Z
dc.date.issued2015
dc.identifier.issn0269-8811
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2314
dc.description.abstractReportedly, negative modulation of alpha(5) GABA(A) receptors may improve cognition in normal and pharmacologically-impaired animals, and such modulation has been proposed as an avenue for treatment of cognitive symptoms in schizophrenia. This study assessed the actions of PWZ-029, administered at doses (2, 5, and 10 mg/kg) at which it reached micromolar concentrations in brain tissue with estimated free concentrations adequate for selective modulation of alpha(5) GABA(A) receptors, in three cognitive tasks in male Wistar rats acutely treated with the noncompetitive N-methyl-D-aspartate receptor antagonist, MK-801 (0.1 mg/kg), as well in tests of locomotor activity potentiated by MK-801 (0.2 mg/kg) or amphetamine (0.5 mg/kg). In a hormetic-like manner, only 5 mg/kg PWZ-029 reversed MK-801-induced deficits in novel object recognition test (visual recognition memory), whereas in the Morris water maze, the 2 mg/kg dose of PWZ-029 exerted partial beneficial effects on spatial learning impairment. PWZ-029 did not affect recognition memory deficits in social novelty discrimination procedure. Motor hyperactivity induced with MK-801 or amphetamine was not preventable by PWZ-029. Our results show that certain MK-801-induced memory deficits can be ameliorated by negative modulation of alpha(5) GABA(A) receptors, and point to the need for further elucidation of their translational relevance to cognitive deterioration in schizophrenia.en
dc.publisherSage Publications Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175076/RS//
dc.rightsopenAccess
dc.sourceJournal of Psychopharmacology
dc.titleNegative modulation of alpha(5) GABA(A) receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈоксимовић, Срђан; Биаwат, Поонам; Марковић, Бојан; Савић, Мирослав; Цоок, Јамес М.; Станковић, Тамара; Тимић-Стаменић, Тамара;
dc.citation.volume29
dc.citation.issue9
dc.citation.spage1013
dc.citation.epage1024
dc.citation.other29(9): 1013-1024
dc.citation.rankM21
dc.identifier.wos000361815300011
dc.identifier.doi10.1177/0269881115590601
dc.identifier.scopus2-s2.0-84942084235
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1026/2312.pdf
dc.identifier.rcubconv_3400
dc.type.versionpublishedVersion


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